Evidence map›Paper›PMID 40044868›Full record

ArticleNature2025

TIR1-produced cAMP as a second messenger in transcriptional auxin signalling.

Huihuang Chen, Linlin Qi, Minxia Zou, Mengting Lu, Mateusz Kwiatkowski, Yuanrong Pei, Krzysztof Jaworski, Jiří Friml

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Crystal ball time.Nature plants · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Aux/IAAs: specificity and redundancy.Plant signaling & behavior · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huihuang Chen *Institute of Science and Technology Austria, Klosterneuburg, Austria.
Linlin Qi *Institute of Science and Technology Austria, Klosterneuburg, Austria.ORCID 0000-0001-5187-8401
Minxia Zou *Institute of Science and Technology Austria, Klosterneuburg, Austria.
Mengting LuInstitute of Science and Technology Austria, Klosterneuburg, Austria.
Mateusz KwiatkowskiDepartment of Plant Physiology and Biotechnology, Nicolaus Copernicus University in Toruń, Toruń, Poland.ORCID 0000-0002-1473-4545
Yuanrong PeiInstitute of Science and Technology Austria, Klosterneuburg, Austria.
Krzysztof JaworskiDepartment of Plant Physiology and Biotechnology, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Jiří FrimlInstitute of Science and Technology Austria, Klosterneuburg, Austria. jiri.friml@ist.ac.at.ORCID 0000-0002-8302-7596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The phytohormone auxin (Aux) is a principal endogenous developmental signal in plants. It mediates transcriptional reprogramming by a well-established canonical signalling mechanism. TIR1/AFB auxin receptors are F-box subunits of an ubiquitin ligase complex; after auxin perception, they associate with Aux/IAA transcriptional repressors and ubiquitinate them for degradation, thus enabling the activation of auxin response factor (ARF) transcription factors

Indexed as

ArabidopsisArabidopsis ProteinsCyclic AMPSecond Messenger SystemsTranscription FactorsAdenylyl CyclasesF-Box ProteinsGene Expression Regulation, PlantIndoleacetic AcidsPlant RootsProteolysisReceptors, Cell SurfaceSignal TransductionTranscription, GeneticAdenylyl CyclasesArabidopsis ProteinsCyclic AMPF-Box ProteinsIndoleacetic AcidsReceptors, Cell SurfaceTIR1 protein, ArabidopsisTranscription Factors

Identifiers

PMID40044868
PMCPMC12018254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.