Evidence map›Paper›PMID 40044858›Full record

ArticleNature2025

Genome duplication in a long-term multicellularity evolution experiment.

Kai Tong, Sayantan Datta, Vivian Cheng, Daniella J Haas, Saranya Gourisetti, Harley L Yopp, Thomas C Day, Dung T Lac, Ahmad S Khalil, Peter L Conlin and 2 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Growth under pressure: The pros and cons of polyploidy induced by stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kai Tong *School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. kaitong@bu.edu.ORCID 0000-0002-1392-5921
Sayantan Datta *School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Vivian ChengSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Daniella J HaasSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Saranya GourisettiSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Harley L YoppSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Thomas C DaySchool of Physics, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0003-4681-9348
Dung T LacSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0009-0009-8480-7701
Ahmad S KhalilBiological Design Center, Boston University, Boston, MA, USA.ORCID 0000-0002-8214-0546
Peter L ConlinSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-2793-7624
G Ozan BozdagSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-0931-2399
William C RatcliffSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. ratcliff@gatech.edu.ORCID 0000-0002-6837-8355

Funding

Programmable benchtop bioreactors for scalable eco-evolutionary dynamics of the human microbiomeR01AI171100 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KHALIL, AHMAD SAMIR, RAKOFF-NAHOUM, SETH · 2022 to 2025
$4.1M
Using directed evolution to study the origins of multicellular development.R35GM138030 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI William Croft Ratcliff · 2020 to 2026
$2.8M
The Biophysical Foundations of Bacterial Biofilm Growth and SurvivalR35GM138354 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Peter Yunker · 2020 to 2026
$2.0M
NIAID NIH HHS R01 AI171100NIGMS NIH HHS R35 GM138030NIGMS NIH HHS R35 GM138354
6 · The paper itself

Abstract

Whole-genome duplication (WGD) is widespread across eukaryotes and can promote adaptive evolution

Indexed as

Biological EvolutionGene DuplicationGenome, FungalSaccharomyces cerevisiaeAneuploidyCell SizeDiploidyEvolution, MolecularGenetic FitnessSelection, GeneticTetraploidyTime Factors

Identifiers

PMID40044858
PMCPMC12256070

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.