Evidence map›Paper›PMID 40044853›Full record

ArticleNature2025

Sensory input, sex and function shape hypothalamic cell type development.

Harris S Kaplan, Brandon L Logeman, Kai Zhang, Tate A Yawitz, Celine Santiago, Noor Sohail, Mustafa Talay, Changwoo Seo, Serhiy Naumenko, Shannan J Ho Sui and 3 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Article
  4. Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Brain-immune interactions generate pathogen-specific sickness states.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Harris S KaplanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8583-5714
Brandon L LogemanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-9975-3541
Kai ZhangDepartment of Cellular and Molecular Medicine, Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0003-3454-7357
Tate A YawitzDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-9873-8860
Celine SantiagoDepartment of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA, USA.
Noor SohailDepartment of Biostatistics, Harvard Chan School of Public Health, Boston, MA, USA.
Mustafa TalayDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-9046-1366
Changwoo SeoDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Serhiy NaumenkoDepartment of Biostatistics, Harvard Chan School of Public Health, Boston, MA, USA.
Shannan J Ho SuiDepartment of Biostatistics, Harvard Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-6191-4709
David D GintyDepartment of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA, USA.ORCID 0000-0001-9723-8530
Bing RenDepartment of Cellular and Molecular Medicine, Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-5435-1127
Catherine DulacDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA. dulac@fas.harvard.edu.ORCID 0000-0001-5024-5418

Funding

Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2017 to 2021
$64.5M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
Microcircuits underlying murine parental behaviorR01HD082131 · NICHD · HARVARD UNIVERSITY · PI DULAC, CATHERINE · 2015 to 2024
$3.5M
Molecular and Genetic Dissection of Brain Circuits Controlling FeverR01NS112399 · NINDS · HARVARD UNIVERSITY · PI DULAC, CATHERINE · 2020 to 2024
$1.9M
Sex and physiological State dependent molecular characterization of circuits governing parental behaviorR00HD108801 · NICHD · UNIVERSITY OF KENTUCKY · PI Brandon Logeman · 2025 to 2026
$473k
Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental BehaviorK99HD108801 · NICHD · HARVARD UNIVERSITY · PI LOGEMAN, BRANDON · 2023 to 2024
$246k
NHGRI NIH HHS UM1 HG011585NICHD NIH HHS K99 HD108801NICHD NIH HHS R00 HD108801NICHD NIH HHS R01 HD082131NIMH NIH HHS U19 MH114821NINDS NIH HHS R01 NS112399
6 · The paper itself

Abstract

Mammalian behaviour and physiology undergo major changes in early life. Young animals rely on conspecifics to meet their needs and start showing nutritional independence and sex-specific social interactions at weaning and puberty, respectively. How neuronal populations regulating homeostatic functions and social behaviours develop during these transitions remains unclear. We used paired transcriptomic and chromatin accessibility profiling to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, where cell types with key roles in physiological and behavioural control have been identified

Indexed as

HypothalamusNeuronsPreoptic AreaSex CharacteristicsAnimalsChromatinFemaleHomeostasisMaleMiceSignal TransductionSocial BehaviorTranscriptomeChromatin

Identifiers

PMID40044853
PMCPMC12589138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.