ArticleNature2025
Aspirin prevents metastasis by limiting platelet TXA
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adjuvant aspirin for colorectal cancer with PIK3CA-mutated and COX-2 overexpressed tumours: the ASCOLT translational research study and meta-analysis.EBioMedicine · 2026Pooled it
- Synergistic effects of anticoagulants and platelet aggregation inhibitors with immune checkpoint inhibitors in cancer therapy: a comprehensive review of preclinical and clinical evidence.Journal for immunotherapy of cancer · 2026Pooled it
- The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Trial
- The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.Cancer biology & therapy · 2026Review
- Inflammation and carcinogenesis: molecular targets and small-molecule intervention strategies.Journal of enzyme inhibition and medicinal chemistry · 2026Review
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Prophylactic and therapeutic effects of aspirin in cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Article
- Association of Aspirin Use with In-Hospital Mortality in Patients with Radiation-Associated Acute Pneumonitis: Insights from the National Inpatient Sample Database.Healthcare (Basel, Switzerland) · 2026Article
- Prostaglandins: Key players in immunomodulation of the nervous system.Neural regeneration research · 2026Article
- The Cancer Immunotherapy Thromboembolism Assessment: A Novel Score for Predicting Thromboembolic Events in Melanoma Patients Treated With Immune Checkpoint Inhibition.International journal of cancer · 2026Article
- Platelet-derived mitochondrial transfer in cancer metastasis: mechanisms, functional consequences, and translational opportunities.Clinical & experimental metastasis · 2026Review
- Platelets as regulators of anti-tumor immunity: mechanisms and clinical implications.Cancer metastasis reviews · 2026Review
- Ginkgo biloba L. in preventing cardiovascular disease: pharmacological effects, mechanism of action, and therapeutic potential.Acta pharmacologica Sinica · 2026Review
- Precision oncology in adjuvant aspirin therapy for colorectal cancer: emerging genetic markers and persistent uncertainties.EBioMedicine · 2026Article
- Tumor-platelet cross talk in cancer: mechanisms, thrombotic risk, and translational opportunities.Blood advances · 2026Review
- Tumor-Associated Platelets Suppress T-cell Function and Promote Immune Evasion in TNBC via the P-selectin/P-selectin Glycoprotein Ligand 1 Pathway.Cancer research communications · 2026Article
- Reply to correspondence on "Aspirin and hepatocellular carcinoma risk in metabolic dysfunction-associated steatotic liver disease: nationwide cohort study with genetic risk analysis".Clinical and molecular hepatology · 2026Article
- Platelet-Prostate cancer crosstalk driving disparities and therapeutic vulnerabilities.Discover oncology · 2026Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Jie YangDepartment of Pathology, University of Cambridge, Cambridge, UK. jy437@cam.ac.uk.ORCID 0000-0001-9157-0532
Yumi Yamashita-KanemaruDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2475-8858
Benjamin I MorrisDepartment of Pathology, University of Cambridge, Cambridge, UK.
Annalisa ContursiSystems Pharmacology and Translational Therapeutics Laboratory, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Daniel TrajkovskiDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.ORCID 0009-0004-9186-2673
Jingru XuDepartment of Pathology, University of Cambridge, Cambridge, UK.
Ilinca PatrascanDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2740-6767
Jayme BensonDepartment of Pathology, University of Cambridge, Cambridge, UK.
Alexander C EvansDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6363-2684
Alberto G ContiDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0725-337X
Aws Al-DekaDepartment of Pathology, University of Cambridge, Cambridge, UK.
Layla DahmaniDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0009-0003-1069-2370
Adnan Avdic-BelltheusDepartment of Pathology, University of Cambridge, Cambridge, UK.
Baojie ZhangDepartment of Pathology, University of Cambridge, Cambridge, UK.
Hanneke OkkenhaugBabraham Institute, Babraham, UK.
Sarah K WhitesideDepartment of Pathology, University of Cambridge, Cambridge, UK.
Charlotte J ImianowskiDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7116-7591
Alexander J WesolowskiDepartment of Pathology, University of Cambridge, Cambridge, UK.
Louise V WebbFrancis Crick Institute, London, UK.
Simone PuccioLaboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID 0000-0003-4007-4365
Stefania TacconelliSystems Pharmacology and Translational Therapeutics Laboratory, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Annalisa BrunoSystems Pharmacology and Translational Therapeutics Laboratory, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Sara Di BerardinoSystems Pharmacology and Translational Therapeutics Laboratory, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Alessandra De MicheleSystems Pharmacology and Translational Therapeutics Laboratory, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Heidi C E WelchBabraham Institute, Babraham, UK.ORCID 0000-0001-7865-7000
I-Shing YuLaboratory Animal Center, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-2369-5816
Shu-Wha LinDepartment of Clinical Laboratory Science and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0001-6748-5581
Suman MitraInserm UMR1277, CNRS UMR9020-CANTHER, Université de Lille, Lille University Hospital, Lille, France.ORCID 0000-0002-3426-371X
Enrico LugliLaboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID 0000-0002-1964-7678
Louise van der WeydenWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-0645-1879
Klaus OkkenhaugDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9432-4051
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.ORCID 0000-0002-0633-3696
Paola PatrignaniSystems Pharmacology and Translational Therapeutics Laboratory, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
David J AdamsWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0001-9490-0306
Rahul RoychoudhuriDepartment of Pathology, University of Cambridge, Cambridge, UK. rr257@cam.ac.uk.ORCID 0000-0002-5392-1853
Funding
Wellcome Trust
Abstract
Metastasis is the spread of cancer cells from primary tumours to distant organs and is the cause of 90% of cancer deaths globally
Indexed as
AspirinBlood PlateletsCyclooxygenase InhibitorsNeoplasm MetastasisThromboxane A2T-LymphocytesAnimalsCell Line, TumorCell ProliferationCyclooxygenase 1FemaleHumansLiver NeoplasmsLung NeoplasmsLymphocyte ActivationMaleAspirinCyclooxygenase 1Cyclooxygenase InhibitorsRho Guanine Nucleotide Exchange FactorsThromboxane A2
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.