Evidence map›Paper›PMID 40044787›Full record

ArticleScientific reports2025

The association of serum CHI3L1 levels with the presence of Kawasaki disease.

Jialin Zou, Xu He, Wenjuan Li, Yan Duan, Bin Liu, Jun Jiang, Dinghua Luo, Jian Zhao, Gang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jialin ZouDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China.
Xu HeDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China.
Wenjuan LiDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China.
Yan DuanDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China.
Bin LiuDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China.
Jun JiangDepartment of General Surgery (Thyroid Surgery), The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Dinghua LuoDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China.
Jian ZhaoDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China. zhao7253@126.com.
Gang LiDepartment of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China. 479719170@qq.com.

Funding

Clinical Medicine Program of Southwest Medical University NO.2024LCYXZX48Luzhou Municipal People's Government-Southwest Medical University Science and Technology strategic cooperation 2023LZXNYDJ042the Sichuan Science and Technology Program 2022YFS0627
6 · The paper itself

Abstract

Chitinase 3-like protein 1(CHI3L1) has been found to be a biomarker for inflammatory diseases, but the diagnostic value of Kawasaki disease (KD) is not investigated. A total of 180 subjects, including 80 KD patients, 70 febrile controls and 30 healthy controls were recruited. Serum of CHI3L1 were measured with an enzyme-linked immunosorbent assay. The correlation between CHI3L1 and clinical parameters was assessed by Spearman correlation coefficient. Multiple logistic regression was employed to investigate the association between CHI3L1 and the incidence of KD. The diagnostic power was evaluated with the receiver operating characteristic curve analysis. Serum CHI3L1 levels in the KD group were significantly higher than those in the fever control group and healthy group. Compared with fever patients, both patients with incomplete KD and complete KD had higher serum CHI3L1 levels. Serum CHI3L1 levels were positively associated with white blood cell counts, neutrophils, platelet, erythrocyte sedimentation rate, C-reactive protein, alanine aminotransferase and the incidence of KD, and negatively associated with hemoglobin, aspartate aminotransferase and albumin. High CHI3L1 tertiles was significantly associated with the high incidence of KD in the unadjusted or adjusted models. Analysis of the Receiver operating characteristic curves, it was showed that the area under the curve was 0.908, with sensitivity of 0.838 and specificity of 0.8 for continuous CHI3L1, and was 0.884 for categorical CHI3L1, with sensitivity of 0.938 and specificity of 0.643 to distinguish all types of KD, respectively. CHI3L1 had the AUC of 0.901, with sensitivity of 0.826 and specificity of 0.8, and had the area under curve of 0.952, with sensitivity of 0.818 and specificity of 0.971 to discriminate complete KD and incomplete KD from febrile diseases, respectively. Serum of CHI3L1 may be a novel and reliable biomarker for the diagnosis of KD.

Indexed as

Chitinase-3-Like Protein 1Mucocutaneous Lymph Node SyndromeBiomarkersCase-Control StudiesChildChild, PreschoolC-Reactive ProteinFemaleHumansInfantMaleROC CurveBiomarkersCHI3L1 protein, humanChitinase-3-Like Protein 1C-Reactive ProteinBiomarkerChitinase 3-like protein 1Kawasaki disease

Identifiers

PMID40044787
PMCPMC11883033

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