ArticleNature communications2025
Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transmission Pathways of Zoonotic Influenza Viruses and Influencing Factors: A Systematic Review of Recent Findings.Viruses · 2025Pooled it
- Polypore mushroom mycelia as an adjunct to COVID-19 vaccination: a randomized clinical trial.BMC immunology · 2026Trial
- Investigating high pathogenicity avian influenza virus incursions to remote islands: detection of H5N1 on Gough Island in the South Atlantic Ocean.Emerging microbes & infections · 2026Article
- Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Development of a multi-species luciferase-based double-antigen ELISA for the detection of antibodies against influenza A virus H5 clade 2.3.4.4b.Journal of clinical microbiology · 2026Article
- Between-species contagion drives HPAI transmission and mass mortality in seabirds.The Journal of animal ecology · 2026Article
- Detection of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Genotype D1.2 Virus in Swine after Experimental Inoculation.Emerging infectious diseases · 2026Article
- Review
- Article
- Heterogeneous viral-host response at single-cell resolution and viral adaptive mutational atlas in birds and mammals upon H5 influenza virus infection.National science review · 2026Article
- Detection of H5N1-Related PB1 Sequences in a Low Pathogenic H11N2 Virus from South American Migratory Shorebirds.Viruses · 2026Article
- A bivalent mRNA-LNP vaccine confers broad-spectrum protection against both homologous and heterologous H5/H7 highly pathogenic avian influenza viruses in SPF chickens.Veterinary research · 2026Article
- Seabirds' mortalities in Antarctica caused by HPAIV: skuas as a sentinel species.Epidemiology and infection · 2026Article
- Distribution of influenza A virus receptors in tissues of South American marine wildlife.Veterinary research communications · 2026Article
- An overview of HPAI H5N1 clade 2.3.4.4b and its emerging threat in mainland Australia: Identified knowledge gaps.One health (Amsterdam, Netherlands) · 2026Review
- Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers.Nature communications · 2026Article
- Emergence and Evolution of Triple Reassortant Highly Pathogenic Avian Influenza A(H5N1) Virus, Argentina, 2025.Viruses · 2026Article
- Emergence of D1.1 reassortant H5N1 avian influenza viruses in North America.bioRxiv : the preprint server for biology · 2026Article
- Genomic analysis of high pathogenicity avian influenza viruses from Antarctica reveals multiple introductions from South America.Nature communications · 2026Article
- Zoonoethics and Inclusive One Health Governance for H5N1 Panzootic: From Animal Culling to Co-responsibility.Public health ethics · 2026Article
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27 authors.
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Abstract
Highly pathogenic H5N1 avian influenza viruses (HPAIV) belonging to lineage 2.3.4.4b emerged in Chile in December 2022, leading to mass mortality events in wild birds, poultry, and marine mammals and one human case. We detected HPAIV in 7,33% (714/9745) of cases between December 2022-April 2023 and sequenced 177 H5N1 virus genomes from poultry, marine mammals, a human, and wild birds spanning >3800 km of Chilean coastline. Chilean viruses were closely related to Peru's H5N1 outbreak, consistent with north-to-south spread down the Pacific coastline. One human virus and nine marine mammal viruses in Chile had the rare PB2 D701N mammalian-adaptation mutation and clustered phylogenetically despite being sampled 5 weeks and hundreds of kilometers apart. These viruses shared additional genetic signatures, including another mammalian PB2 adaptation (Q591K, n = 6), synonymous mutations, and minor variants. Several mutations were detected months later in sealions in the Atlantic coast, indicating that the pinniped outbreaks on the west and east coasts of South America are genetically linked. These data support sustained mammal-to-mammal transmission of HPAIV in marine mammals over thousands of kilometers of Chile's Pacific coastline, which subsequently continued through the Atlantic coastline.
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