Evidence map›Paper›PMID 40044702›Full record

ArticleScientific reports2025

The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery.

Chia-Yi Lee, Hung-Chi Chen, Shun-Fa Yang, Yi-Jen Hsueh, Jing-Yang Huang, Chao-Kai Chang

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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4 citing papers in PubMed.

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5 · Who and what money

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6 authors.

Chia-Yi Lee *Institute of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan.
Hung-Chi Chen *Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, 333, Taiwan.
Shun-Fa Yang *Institute of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan.
Yi-Jen HsuehDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, 333, Taiwan.
Jing-Yang HuangDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, 402, Taiwan.
Chao-Kai ChangNobel Eye Institute, Taipei, 115, Taiwan. chaokai@ms17.hinet.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate influence of total antioxidant capacity expression (TAC) on outcome of kerato-lenticule extraction (KLEx). A prospective non-randomized trial was conducted and patients received KLEx were categorized via TAC concentration. A total of 56 and 36 eyes were enrolled into the low TAC and high TAC groups. The main outcomes are the postoperative un-corrected visual acuity (UCVA), refraction and superficial keratitis between groups. The generalized liner model was applied for statistical analysis. One month after the KLEx surgery, the UCVA was significantly higher in the high TAC group (P = 0.028), and low TAC group associated with superficial keratitis risk compared to high TAC group (P = 0.035). The trends of TAC and ascorbic acid (AA) decrements were more significant in the low TAC group (both P < 0.05). Low TAC population and old age correlated to poor UCVA (both P < 0.05) while the thick CCT correlated to better UCVA (P = 0.030). Besides, the low TAC population (P = 0.032) correlated to higher superficial keratitis rate, while old age (P = 0.018) correlated to lower superficial keratitis rate. The presence of low TAC expression correlated to worse UCVA and higher risk of superficial keratitis after KLEx.

Indexed as

AntioxidantsMyopiaAdultAscorbic AcidFemaleHumansKeratitisMaleMiddle AgedPreoperative PeriodProspective StudiesTreatment OutcomeVisual AcuityYoung AdultAntioxidantsAscorbic AcidAscorbic acidKerato-lenticule extractionSuperficial keratitisTotal antioxidant capacityUn-corrected visual acuity

Identifiers

PMID40044702
PMCPMC11882917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.