Evidence map›Paper›PMID 40044701›Full record

ArticleNature communications2025

Structural basis for transcription activation through cooperative recruitment of MntR.

Haoyuan Shi, Yu Fu, Vilmante Kodyte, Amelie Andreas, Ankita J Sachla, Keikilani Miller, Ritu Shrestha, John D Helmann, Arthur Glasfeld, Shivani Ahuja

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025
    Review
  5. Article
  6. Article
  7. SloR-SRE binding to theJournal of bacteriology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Haoyuan ShiDepartment of Chemistry, Reed College, Portland, Oregon, USA.ORCID http://orcid.org/0000-0002-1822-6230
Yu FuDepartment of Chemistry, Reed College, Portland, Oregon, USA.
Vilmante Kodyte *Department of Chemistry, Reed College, Portland, Oregon, USA.ORCID http://orcid.org/0000-0001-9051-1602
Amelie Andreas *Department of Chemistry, Reed College, Portland, Oregon, USA.ORCID http://orcid.org/0009-0001-8899-2184
Ankita J SachlaDepartment of Microbiology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-3850-5421
Keikilani MillerDepartment of Chemistry, Reed College, Portland, Oregon, USA.
Ritu ShresthaRefeyn Inc, Portland, Oregon, USA.ORCID http://orcid.org/0000-0002-4753-0872
John D HelmannDepartment of Microbiology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-3832-3249
Arthur GlasfeldDepartment of Chemistry, Reed College, Portland, Oregon, USA.ORCID http://orcid.org/0000-0003-0680-0263
Shivani AhujaDepartment of Chemistry, Reed College, Portland, Oregon, USA. ahujas@reed.edu.ORCID http://orcid.org/0000-0002-0123-711X

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Bacillus subtilis Stress ResponsesR35GM122461 · NIGMS · CORNELL UNIVERSITY · PI John D Helmann · 2017 to 2026
$7.6M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R35GM122461NIGMS NIH HHS R35 GM122461NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Bacillus subtilis MntR is a dual regulatory protein that responds to heightened Mn

Indexed as

Bacillus subtilisBacterial ProteinsRepressor ProteinsTranscriptional ActivationBinding SitesCryoelectron MicroscopyGene Expression Regulation, BacterialManganeseModels, MolecularPromoter Regions, GeneticProtein BindingProtein MultimerizationBacterial ProteinsManganeseMntR protein, bacteriaRepressor Proteins

Identifiers

PMID40044701
PMCPMC11882963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.