ArticleAngewandte Chemie (International ed. in English)2025
Regio- and Enantioconvergent Hydroallylation of Acrylates Enabled by γ-Silyl-Substituted Allyl Acetates.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Directing Effects of Silyl and Germyl Groups in Transition-Metal-Catalyzed Allylic Substitution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Regio- and Enantioconvergent Hydroallylation of Acrylates Enabled by γ-Silyl-Substituted Allyl Acetates.Angewandte Chemie (International ed. in English) · 2025Article
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5 authors.
Funding
Abstract
Transition-metal-catalyzed asymmetric allylic substitution provides an efficient route to chiral organic molecules featuring an allyl moiety, key intermediates in the synthesis of biologically active compounds. However, the use of unsymmetrical 1,3-disubstituted allyl electrophiles has been severely constrained by the challenges of achieving both regio- and stereoselectivity simultaneously. Herein, we present γ-silyl-substituted allyl acetates as highly effective electrophiles for a regio- and enantioconvergent hydroallylation, enabling the construction of vicinal stereogenic centers. This method delivers allylated products in 44%-93% yield with 79:21 to >95:5 dr and 88% to >99% ee. Additionally, the silyl group in the products can be readily converted into other functional groups, such as acyl and aryl groups, enhancing their synthetic utility.
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