ArticleBMJ paediatrics open2025
Acute kidney injury in late-onset neonatal bacteraemia: The role of the neonatal sequential organ failure assessment tool in predicting kidney injury.
Article in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Renal resistive index and neonatal sequential organ failure assessment score as acute kidney injury risk predictors in preterm neonates with late-onset neonatal sepsis.Frontiers in nephrology · 2026Article
- Metabolomics of Sepsis and Acute Kidney Injury in Infants and Children: Current Challenges in Prevention, Diagnosis, and Management.Infectious diseases and therapy · 2025Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionNeonatal sepsis remains a leading cause of morbidity and mortality across all healthcare systems. Acute kidney injury (AKI) is common in neonates and is associated with poor clinical outcomes. We sought to profile the incidence of AKI in infants with culture-positive bacteraemia and to assess the utility of the neonatal sequential organ failure (nSOFA) tool in AKI prediction.
methodsA single-centre retrospective review of infants with culture-positive bacteraemia was performed at the Rotunda Hospital, Dublin, Ireland. Clinical, demographic and biochemical data were collated, with the modified neonatal Kidney Disease: Improving Global Outcomes (KDIGO) criteria and nSOFA scoring applied to each included patient.
resultsOur cohort of n=35 patients with culture-positive bacteraemia had an AKI incidence of 48.6%. There was no statistically significant association between peak nSOFA and the development of AKI.
conclusionThe incidence of AKI in late-onset neonatal clinically significant bacteraemia is high. nSOFA within 24 hours of culture has poor utility in predicting acute kidney injury in neonatal patients with culture-positive bacteraemia.
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