Evidence map›Paper›PMID 40043703›Full record

ArticleCell2025

Mapping the landscape of social behavior.

Ugne Klibaite, Tianqing Li, Diego Aldarondo, Jumana F Akoad, Bence P Ölveczky, Timothy W Dunn

Abstract readVideo-Audio Media
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Whole-body 3D kinematics of freely behavingbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Neural Bases of Collective Social Behavior and Group Interactions across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  12. Cortex-Wide Substrates for Body Schema and Action Awareness.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  15. Article
  16. Context rescales a social action code in a hormone-sensitive network.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. DIPLOMAT: multi-animal tracking with efficient manual editing.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ugne KlibaiteDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: klibaite@fas.harvard.edu.
Tianqing LiDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Diego AldarondoDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Jumana F AkoadDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Bence P ÖlveczkyDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: olveczky@fas.harvard.edu.
Timothy W DunnDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA. Electronic address: timothy.dunn@duke.edu.

Funding

A system for long-term high-resolution 3D tracking of movement kinematics in freely behaving animalsR01GM136972 · NIGMS · HARVARD UNIVERSITY · PI OLVECZKY, BENCE P · 2021 to 2024
$1.9M
High-resolution 3D tracking of social behaviors for deep phenotypic analysisR34DA059506 · NIDA · DUKE UNIVERSITY · PI DUNN, TIMOTHY WILLIAM, OLVECZKY, BENCE P · 2024 to 2025
$741k
High-throughput, high-resolution 3D measurement of ethologically relevant rodent behavior in a dynamic environmentR34DA059512 · NIDA · DUKE UNIVERSITY · PI DUNN, TIMOTHY WILLIAM, FIELD, GREGORY DARIN · 2024 to 2025
$713k
The Virtual Rodent: A Platform to Study the Artificial and Biological Control of Natural BehaviorF99NS125834 · NINDS · HARVARD MEDICAL SCHOOL · PI ALDARONDO, DIEGO ETIONY · 2022 to 2023
$65k
NIDA NIH HHS R34 DA059506NIDA NIH HHS R34 DA059512NIGMS NIH HHS R01 GM136972NINDS NIH HHS F99 NS125834
6 · The paper itself

Abstract

Social interaction is integral to animal behavior. However, lacking tools to describe it in quantitative and rigorous ways has limited our understanding of its structure, underlying principles, and the neuropsychiatric disorders, like autism, that perturb it. Here, we present a technique for high-resolution 3D tracking of postural dynamics and social touch in freely interacting animals, solving the challenging subject occlusion and part-assignment problems using 3D geometric reasoning, graph neural networks, and semi-supervised learning. We collected over 110 million 3D pose samples in interacting rats and mice, including seven monogenic autism rat lines. Using a multi-scale embedding approach, we identified a rich landscape of stereotyped actions, interactions, synchrony, and body contacts. This high-resolution phenotyping revealed a spectrum of changes in autism models and in response to amphetamine not resolved by conventional measurements. Our framework and large library of interactions will facilitate studies of social behaviors and their neurobiological underpinnings.

Indexed as

Social BehaviorAnimalsAutistic DisorderBehavior, AnimalBiomechanical PhenomenaFemaleImaging, Three-DimensionalMaleMiceRats3D animal poseanimal behaviorASDautismcomputer visionhigh-resolution phenotypingmachine learningneurosciencesocial behavior

Identifiers

PMID40043703
PMCPMC12010356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.