Evidence map›Paper›PMID 40043688›Full record

ArticleCell metabolism2025

"Shunt-ing" down obesity with novel endogenous metabolites.

Victor J Pai, Alan Saghatelian

Abstract read
In one paragraph

Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Victor J PaiClayton Foundation Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Alan SaghatelianClayton Foundation Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA, USA. Electronic address: asaghatelian@salk.edu.

Funding

An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and DiseaseRC2DK129961 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T, COHEN, PAUL · 2021 to 2025
$9.2M
Regulation of the biosynthesis of a novel class of anti-diabetic lipidsR01DK106210 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAHN, BARBARA B., SAGHATELIAN, ALAN · 2016 to 2024
$6.6M
The Discovery of Human Peptide Encoding GenesR01GM102491 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'SHEA, CLODAGH, SAGHATELIAN, ALAN · 2012 to 2025
$5.5M
Function and metabolism of aging lipids in the brainRF1AG086547 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ELLISMAN, MARK H, SAGHATELIAN, ALAN · 2024 to 2024
$2.2M
Trimming the fat with small proteins: Micropeptides in adipogenesisF32DK132927 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PAI, VICTOR JIEH PONG · 2022 to 2024
$226k
NIA NIH HHS RF1 AG086547NIDDK NIH HHS F32 DK132927NIDDK NIH HHS R01 DK106210NIDDK NIH HHS RC2 DK129961NIGMS NIH HHS R01 GM102491
6 · The paper itself

Abstract

Obesity is a growing public health issue that has recently been transformed through the advent of new medicines. However, our understanding of the pathways and mechanisms that regulate energy balance in mammals is still developing. Recent discoveries on this front include an exciting new finding that there exists a novel class of metabolites in humans and mice that can regulate obesity in rodents.

Indexed as

ObesityAnimalsEnergy MetabolismHumansMice

Identifiers

PMID40043688
PMCPMC12687471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.