Evidence map›Paper›PMID 40043467›Full record

ArticleNeurobiology of aging2025

Relation of MRI visible perivascular spaces with global and regional brain structural connectivity measures: The Framingham Heart Study (FHS).

Oluchi Ekenze, Stephan Seiler, Adlin Pinheiro, Charles DeCarli, Pedram Parva, Mohamad Habes, Andreas Charidimou, Pauline Maillard, Alexa Beiser, Sudha Seshadri and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Oluchi EkenzeNHLBI's Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA.
Stephan SeilerDepartment of Neurology, Medical University of Graz, Austria; Division of Neuroradiology, Vascular and Interventional Radiology, Medical University of Graz, Graz 8036, Austria.
Adlin PinheiroNHLBI's Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA.
Charles DeCarliDepartment of Neurology, University of California at Davis, Davis, CA, USA.
Pedram ParvaDepartment of Radiology, Veterans Affairs Boston Health System, Boston, MA 02130, USA.
Mohamad HabesDepartment of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA.
Andreas CharidimouDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, 72 E Concord Street, Boston, MA 02118, USA.
Pauline MaillardDepartment of Neurology, University of California at Davis, Davis, CA, USA.
Alexa BeiserNHLBI's Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, 72 E Concord Street, Boston, MA 02118, USA.
Sudha SeshadriNHLBI's Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.
Serkalem DemissieNHLBI's Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA.
Jose Rafael RomeroNHLBI's Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, 72 E Concord Street, Boston, MA 02118, USA. Electronic address: joromero@bu.edu.

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
Cerebral tau deposition and comorbid cerebrovascular disease across the Alzheimer's disease continuum in Mexican AmericansR01AG085571 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GONZALES, MITZI MICHELLE, HABES, MOHAMAD · 2024 to 2025
$5.7M
Collaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4M
Novel imaging and endothelial biomarkers of small vessel cerebrovascular diseaseUH3NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DECARLI, CHARLES, KRAMER, JOEL H · 2018 to 2020
$3.5M
Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequencesR01AG059725 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROMERO, JOSE RAFAEL · 2019 to 2023
$3.1M
Multiethnic machine learning brain signatures of ADRDR01AG080821 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HABES, MOHAMAD · 2022 to 2025
$2.9M
Vascular Imaging Biomarker Relationships to Alzheimer’s disease (VIBRA)R01AG083865 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes, Timothy M. Hughes · 2024 to 2026
$2.3M
Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham StudyK23AG038444 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROMERO, JOSE RAFAEL · 2011 to 2015
$644k
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NIA NIH HHS K23 AG038444NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG059725NIA NIH HHS R01 AG080821NIA NIH HHS R01 AG083865NIA NIH HHS R01 AG085571NIA NIH HHS R03 AG048180NINDS NIH HHS R01 NS017950NINDS NIH HHS R21 NS135268NINDS NIH HHS UH3 NS100608
6 · The paper itself

Abstract

MRI visible perivascular spaces (PVS) are associated with cognitive impairment and dementia, which are also associated with disrupted network connectivity. PVS may relate to dementia risk through disruption in brain connectivity. We studied the relation between PVS grade and global and regional structural connectivity in Framingham Heart Study participants free of stroke and dementia. PVS were rated on axial T2 sequences in the basal ganglia (BG) and centrum semiovale (CSO). We assessed structural global and regional network architecture using global efficiency, local efficiency and modularity. Analysis of covariance was used to relate PVS grades with structural network measures. Models adjusted for age, sex (model 1), and vascular risk factors (model 2). Effect modification on the associations by age, sex, hypertension and APOE-ɛ4 status was assessed. Among 2525 participants (mean age 54 ± 13 years, 53 % female), significant associations were observed between grade III and IV PVS in the BG and CSO with reduced global efficiency. Grade III (β -0.0030; 95 % confidence interval [CI] -0.0041, -0.0019) and IV (β -0.0033, CI -0.0060, -0.0007) PVS in the BG and grade IV (β -0.0015; CI -0.0024, -0.0007) PVS in the CSO were associated with reduced local efficiency. We observed shared and different strength of association by age, hypertension, sex and APOE-ɛ4 in the relationship between high burden PVS in the BG and CSO with structural network measures. Findings suggest that higher grade PVS are associated with disruption of global and regional structural brain networks.

Indexed as

BrainGlymphatic SystemMagnetic Resonance ImagingAdultAgedCognitive DysfunctionDementiaFemaleHumansMaleMiddle AgedRisk FactorsBasal gangliaCentrum semiovaleGlobal efficiencyLocal efficiencyModularityMRI visible perivascular spacesStructural brain connectivity

Identifiers

PMID40043467
PMCPMC11981825

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