ArticleNeurology2025
Association Between Self-Perceived Stress and Cryptogenic Ischemic Stroke in Young Adults: A Case-Control Study.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01934725 (Searching for Explanations for Cryptogenic Stroke in the Young), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO)
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Psychosocial stress and stroke risk: meta-analysis of observational studies.Frontiers in neurology · 2025Pooled it
- The association between self-perceived stress and ischemic stroke risk: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- The correlation between perceived psychosocial stress and stroke: a meta-analysis.Frontiers in neurology · 2025Pooled it
- The mediating role of inflammation and nutrition metabolism in the methylmalonic acid-stroke association.Clinics (Sao Paulo, Brazil) · 2026Article
- Exploring key stakeholder perceptions on the impact of younger stroke: a multinational, qualitative interview study.BMJ open · 2026Article
- Acute non-alcoholic caffeinated beverage consumption as a trigger for cryptogenic ischemic stroke in the young: findings from the SECRETO study.Journal of neurology · 2026Observational
- Association between education level and depressive symptom trajectories in middle-aged and older Chinese adults: a nationally representative cohort study.BMC psychology · 2026Article
- Association Between Physical Activity and Cryptogenic Ischemic Stroke in Young Adults: A Case-Control Study.European journal of neurology · 2026Article
- Deep Vein Thrombosis Prevention in Acute Ischemic Stroke Patients with Lower Limb Paralysis: A Narrative Review.Journal of clinical medicine · 2026Review
- ESO annual stroke evidence update 2025.European stroke journal · 2026Review
- Association Between Living Environmental Factors and Stroke in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study.Journal of the American Heart Association · 2026Article
- A Qualitative Study of Unplanned Hospital Readmissions: Patient Perspectives on Their Hospital to Home Transition.Nursing reports (Pavia, Italy) · 2025Article
- A 360° perspective on cardiovascular prevention: the International Lipid Expert Panel SiMple tIps for the heaLthy hEart (ILEP-SMILE).Archives of medical science : AMS · 2025Article
- Global, regional, and national burden of ischemic heart disease in youths and young adults aged 15-39 years in 204 countries/territories, 1990-2021: a systematic analysis of global burden of disease study 2021.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
32 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPsychosocial stress is a potentially modifiable risk factor of early-onset ischemic stroke, with limited evidence suggesting a stronger association between stress and cryptogenic ischemic stroke (CIS) compared with strokes of known etiology. We aimed to explore the association between self-perceived stress and CIS, with subgroup analyses stratified by sex and age.
methodsYoung patients aged 18-49 years with a first-ever CIS and sex-matched and age-matched stroke-free controls from 19 European centers were included. Self-perceived stress was assessed using a modified version of the Perceived Stress Scale (PSS). Scores were categorized into low (0-13), moderate (14-26), and high (27-40) perceived stress. Conditional logistic regression-adjusted for age, level of education, traditional risk factors (hypertension, cardiovascular diseases, diabetes mellitus, heavy alcohol consumption, current smoking, obesity, diet, depression, and physical inactivity), and migraine with aura (MA)-was used to assess independent association between self-perceived stress and CIS.
resultsAltogether, 426 patients (median age 41 years; 47.7% women) and 426 controls were included. Patients were more often at least moderately stressed compared with controls (46.2% vs 33.3%, DISCUSSION: Self-perceived stress was strongly correlated with an increased risk of early-onset CIS, even after robust adjustment for cardiovascular risk factors and MA. These findings highlight the need for further investigation into the mechanisms by which stress may contribute to the risk of CIS. Possibility of recall bias should be considered when interpreting the results. TRIAL REGISTRATION INFORMATION: Clinical trial registration number: NCT01934725.
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