ArticleDeutsches Arzteblatt international2025
Clinical Features in Patients With Early-Onset Colorectal Cancer: An Evaluation of Data From the StuDoQ Database.
Article in Deutsches Arzteblatt international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- [Can a fast-track protocol for elective colorectal resections be sustained in the clinical routine of German hospitals?]Chirurgie (Heidelberg, Germany) · 2026Article
- Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer.JNCI cancer spectrum · 2026Article
- Correlation between baseline magnetic resonance imaging features and serum carcinoembryonic antigen levels in patients with primary rectal cancer.World journal of gastrointestinal oncology · 2025Article
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15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of colorectal cancer (CRC) in patients who are less than 50 years old (early-onset colorectal cancer, EO-CRC) has risen markedly around the world in recent decades. Because of a lack of early detection programs for young patients, EO-CRC is often not detected until it has reached an advanced stage. In this study, we compared surgical patients with EO-CRC to those with so-called average-onset CRC (> 50 years; AO-CRC) using data from a large patient collective.
methods63 565 cases of CRC from the years 2013-2022 were identified in the StuDoQ database of the German Society for General and Visceral Surgery (Deutsche Gesellschaft für Allgemeinund Viszeralchirurgie, DGAV) and were analyzed on the basis of tumor-related and perioperative data for each of two groups, EO-CRC (3549 patients) and AO-CRC (60 016 patients).
resultsThe mean age in the two groups was 42.50 ± 6.3 and 71.59 ± 10.3 years. In the EO-CRC group, 26.2% of the patients were under 40, and 50.4% were under 45. Men predominated in both groups. The distribution of tumor sites differed, with more rectal carcinoma and left-sided CRC in the EO-CRC group. More patients had nodal or distant metastases in the EO-CRC group. Compared to patients in the AO-CRC group, those in the EO-CRC group much more commonly had inflammatory bowel disease (OR 5.83, 95% confidence interval [4.73; 7.16]), a genetic predisposition (OR 4.36 [3.54;5.35]), or a positive family history (OR 4.54 [4.17; 4.95]).
conclusionThis analysis reveals that patients with EO-CRC differ markedly from those with AO-CRC in tumor-related data, multimodal treatment approaches, and perioperative outcomes. Risk-based, individualized early detection programs should be established to prevent the progression of undetected EO-CRC.
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