Evidence map›Paper›PMID 40043207›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Continuous On-Demand Diaphragm Neurostimulation to Prevent Diaphragm Inactivity During Mechanical Ventilation: A Phase 1 Clinical Trial (STIMULUS).

Idunn S Morris, Thiago Bassi, Catherine A Bellissimo, Paweenuch Bootjeamjai, Georgiana Roman-Sarita, Marc de Perrot, Laura Donahoe, Karen McRae, Jose Dianti, Lorenzo Del Sorbo and 9 more

Abstract readClinical Trial, Phase I
PubMed Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Idunn S MorrisDepartment of Physiology.ORCID 0000-0001-9943-1684
Thiago BassiDivision of Respirology, Department of Medicine.
Catherine A BellissimoToronto General Hospital Research Institute, Toronto, Ontario, Canada.
Paweenuch BootjeamjaiFaculty of Medicine, Department of Anesthesiology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand.
Georgiana Roman-SaritaDepartment of Respiratory Therapy.
Marc de PerrotDivision of Thoracic Surgery, Department of Surgery, and.
Laura DonahoeDivision of Thoracic Surgery, Department of Surgery, and.
Karen McRaeDepartment of Anesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada.
Jose DiantiInterdepartmental Division of Critical Care Medicine.
Lorenzo Del SorboInterdepartmental Division of Critical Care Medicine.ORCID 0000-0003-3294-9838
Shaf KeshavjeeToronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, and.ORCID 0000-0003-4547-8094
Marcelo CypelToronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, and.ORCID 0000-0001-5652-1938
Steven C ReynoldsIntensive Care Unit, Royal Columbian Hospital, Fraser Health Authority, New Westminster, British Columbia, Canada.
Martin DresUnite Mixte de Recherche-Sorbonne 1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Institut National de la Sante et de la Recherche Medicale, Sorbonne Université, Paris, France.ORCID 0000-0001-9191-6089
Viral ThakkarLungpacer Medical USA Inc., Exton, Pennsylvania.
Nawzer MehtaLungpacer Medical USA Inc., Exton, Pennsylvania.
Laurent BrochardInterdepartmental Division of Critical Care Medicine.
Niall D FergusonDepartment of Physiology.
Ewan C GoligherDepartment of Physiology.ORCID 0000-0002-0990-6701

Funding

National Sanitarium Association
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DiaphragmElectric Stimulation TherapyRespiration, ArtificialRespiratory InsufficiencyAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedTreatment Outcomediaphragmlung injuryphrenic nerverespiratory failurerespiratory muscles

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.