Evidence map›Paper›PMID 40043172›Full record

ArticleEuropean heart journal. Acute cardiovascular care2025

Mechanical ventilation in acute pulmonary embolism: a randomized, experimental, crossover study.

Cecilie Dahl Baltsen, Mark Stoltenberg Ellegaard, Casper Nørholt, Simone Juel Dragsbaek, Christopher Kabrhel, Asger Andersen, Asger Granfeldt, Mads Dam Lyhne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Acute cardiovascular care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cecilie Dahl BaltsenDepartment of Anaesthesiology and Intensive Care, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200 Aarhus N, Denmark.
Mark Stoltenberg EllegaardDepartment of Anaesthesiology and Intensive Care, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200 Aarhus N, Denmark.
Casper NørholtDepartment of Anaesthesiology and Intensive Care, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200 Aarhus N, Denmark.
Simone Juel DragsbaekDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark.ORCID 0000-0001-9021-8975
Christopher KabrhelDepartment of Emergency Medicine, Center for Vascular Emergencies, Massachusetts General Hospital, 125 Nashua Street, Suite 460, Boston, 02114 MA, USA.ORCID 0000-0002-8699-7176
Asger AndersenDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark.ORCID 0000-0002-9102-3130
Asger GranfeldtDepartment of Anaesthesiology and Intensive Care, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200 Aarhus N, Denmark.ORCID 0000-0002-7241-6131
Mads Dam LyhneDepartment of Anaesthesiology and Intensive Care, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200 Aarhus N, Denmark.ORCID 0000-0001-5279-260X

Funding

Supplemental Oxygen for Pulmonary Embolism (SO-PE) - A Mechanistic Clinical TrialR01HL168040 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER KABRHEL · 2023 to 2026
$2.3M
Danish Society of Anaesthesiology and Intensive CareFonden til Lægevidenskabens Fremme L-2022-00176Helga og Peter Kornings Fond DC472123- 007-30Karen Elise Jensens FondNHLBI NIH HHS R01 HL168040NIH HHS 1R01HL168040-01Oda og Hans Svenningsens fondSnedkermester Jacobsen og hustru Astrid Jacobsens FondUnited States of America
6 · The paper itself

Abstract

aimsAcute intermediate-high-risk pulmonary embolism (PE) causes a pathological increase in pulmonary artery pressure and right ventricle afterload that may progress to right ventricle failure and cardiopulmonary collapse. Patients may require mechanical ventilation, further increasing pulmonary vascular resistance (PVR) and artery pressure. We aimed to investigate the ability of ventilator settings adjustments to reduce pulmonary artery pressure in a porcine model. METHODS AND

resultsEleven Danish female pigs (Landrace/Yorkshire/Duroc) of ≈60 kg were used to perform a randomized, blinded, cross-over, experimental study. Following induction of acute PE, the animals were subject to four randomized interventions with wash-out periods in between: (1) changes in positive end-expiratory pressure (PEEP) (from 5 to 0, 10 and 15 cmH2O), (2) 50 and 100% increase in minute ventilation (hypocapnia), (3) increase in fraction of inspired oxygen (FiO2, from 21 to 40%), and (4) infusion of sodium bicarbonate to induce alkalosis. The main outcome was mean pulmonary artery pressure (mPAP). mPAP was reduced by a reduction in PEEP (28 ± 6 vs. 26 ± 5 mmHg, P = 0.011), hypocapnia (27 ± 6 vs. 23 ± 5 mmHg, P = 0.0004), alkalosis (27 ± 4 vs. 25 ± 5 mmHg, P = 0.003), and increased fraction of inspired oxygen (28 ± 6 vs. 23 ± 5 mmHg, P < 0.0001). Changes in PVR showed similar patterns (P < 0.05 for all).

conclusionIn a porcine model of acute PE reduction of PEEP, permissive hypocapnia through hyperventilation, alkalosis, and increased fraction of inspired oxygen can reduce mPAP.

Indexed as

Positive-Pressure RespirationPulmonary EmbolismRespiration, ArtificialAcute DiseaseAnimalsCross-Over StudiesDisease Models, AnimalFemalePulmonary ArteryRandom AllocationSwineVascular ResistanceAlkalosisHypocapniaOxygenPositive end-expiratory pressurePulmonary artery pressureRight ventricular function

Identifiers

PMID40043172
PMCPMC12641526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.