Evidence map›Paper›PMID 40043121›Full record

ArticleScience advances2025

Oxytocin induces embryonic diapause.

Jessica L Minder, Sarah B Winokur, Janaye Stephens, Jie Tong, Naomi L Cassel, Luisa Schuster, Habon A Issa, Michael Cammer, Latika Khatri, Gaia Moisan and 8 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jessica L MinderSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-5020-4739
Sarah B WinokurSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-8489-9871
Janaye StephensNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Jie TongDepartment of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
Naomi L CasselSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0009-0005-7437-5387
Luisa SchusterSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-8954-0737
Habon A IssaSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Michael CammerMicroscopy Laboratory, Division of Advanced Research Technologies, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-4930-1739
Latika KhatriSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Gaia MoisanSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Maria Alvarado-TorresSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-5482-2446
Orlando AristizábalSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-9912-135X
Youssef Z WadghiriCenter for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-7175-9397
Sang Yong KimDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Silvana ValtchevaSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-3279-9921
Catherine Pei-Ju LuDepartment of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
Moses V ChaoSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Robert C FroemkeSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-1230-6811

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Adam Christopher Mar · 2018 to 2026
$36.4M
Neural circuitry of oxytocin signaling for alloparenting behavior- Revision - 1R01HD088411 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Robert Crooks Froemke · 2017 to 2026
$5.2M
Training Systems and Integrative NeuroscienceT32MH019524 · NIMH · NEW YORK UNIVERSITY · PI KIORPES, LYNNE · 1992 to 2025
$5.2M
Molecular Mechanisms in Sweat Gland DevelopmentR01AR080136 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Catherine Pei-Ju Lu · 2023 to 2026
$2.2M
Molecular mechanisms in sweat gland innervationR01AR082033 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Catherine Pei-Ju Lu · 2024 to 2026
$2.0M
Hypothalamic Activity and Collective Mouse Behavior in Lab Cages vs Outdoor ColoniesR34NS138066 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FROEMKE, ROBERT CROOKS, GRAHAM, ANDREA L. · 2024 to 2025
$754k
Molecular mechanism of neuronal control in sweat gland developmentR56AR082033 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LU, CATHERINE PEI-JU · 2023 to 2023
$372k
NCI NIH HHS P30 CA016087NIAMS NIH HHS R01 AR080136NIAMS NIH HHS R01 AR082033NIAMS NIH HHS R56 AR082033NICHD NIH HHS R01 HD088411NIMH NIH HHS T32 MH019524NINDS NIH HHS R34 NS138066NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Embryonic development in many species, including case reports in humans, can be temporarily halted before implantation during a process called diapause. Facultative diapause occurs under conditions of maternal metabolic stress such as nursing. While molecular mechanisms of diapause have been studied, a natural inducing factor has yet to be identified. Here, we show that oxytocin induces embryonic diapause in mice. We show that gestational delays were triggered during nursing or optogenetic stimulation of oxytocin neurons simulating nursing patterns. Mouse blastocysts express oxytocin receptors, and oxytocin induced delayed implantation-like dispersion in cultured embryos. Last, oxytocin receptor-knockout embryos transferred into wild-type surrogates had low survival rates during diapause. Our results indicate that oxytocin coordinates timing of embryonic development with uterine progression through pregnancy, providing an evolutionarily conserved mechanism for ensuring successful reproduction.

Indexed as

DiapauseEmbryo, MammalianEmbryonic DevelopmentOxytocinAnimalsBlastocystEmbryo ImplantationFemaleMiceMice, KnockoutPregnancyReceptors, OxytocinOxytocinReceptors, Oxytocin

Identifiers

PMID40043121
PMCPMC11881891

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.