Evidence map›Paper›PMID 40042941›Full record

ArticleMolecular biology of the cell2025

PP2A-B56 regulates Mid1 protein levels for proper cytokinesis in fission yeast.

Madeline L Chrupcala, James B Moseley

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Madeline L ChrupcalaDepartment of Biochemistry and Cell Biology, The Geisel School of Medicine at Dartmouth, Hanover, NH.
James B MoseleyDepartment of Biochemistry and Cell Biology, The Geisel School of Medicine at Dartmouth, Hanover, NH.

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Mechanisms controlling cell size and shapeR35GM149248 · NIGMS · DARTMOUTH COLLEGE · PI James B Moseley · 2023 to 2026
$2.3M
NIGMS NIH HHS P20 GM113132NIGMS NIH HHS R35 GM149248
6 · The paper itself

Abstract

Protein phosphorylation regulates many steps in the cell division process including cytokinesis. In fission yeast cells, the anillin-like protein Mid1 sets the cell division plane and is regulated by phosphorylation. Multiple protein kinases act on Mid1, but no protein phosphatases have been shown to regulate Mid1. Here, we discovered that the conserved protein phosphatase PP2A-B56 is required for proper cytokinesis by promoting Mid1 protein levels. We find that

Indexed as

CytokinesisProtein Phosphatase 2SchizosaccharomycesSchizosaccharomyces pombe ProteinsPhosphorylationMid1 protein, S pombeProtein Phosphatase 2Schizosaccharomyces pombe Proteins

Identifiers

PMID40042941
PMCPMC12005099

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.