ArticleInvestigative ophthalmology & visual science2025
One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Bupivacaine-Induced Regeneration in Rabbit Extraocular Muscles: Implications for the Treatment of Strabismus.Ophthalmology science · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To explore whether there is a difference in postoperative extraocular muscle (EOM) remodeling between 1-month-old and 3-month-old rabbits. Methods: Recession (n = 16) and resection (n = 16) were performed on the right superior rectus (SR) muscles of 1-month-old and 3-month-old rabbits. SR tissues were harvested 1 and 4 weeks post-surgery (n = 4 for each group), and mid-belly sections were used to assess myosin heavy chain (MyHC) isoform expression (fast 2X, embryonic, and neonatal MyHCs), activated satellite cells (SCs), and centrally nucleated myofibers. Age-matched unoperated rabbits (n = 4) served as controls. Results: In 1-month-old rabbits, fast 2X-MyHC expression continuously decreased post-recession (all P < 0.01), and embryonic MyHC expression increased both post-recession and post-resection (all P < 0.01), except in the global layer (GL) post-resection. In 3-month-old rabbits, fast 2X-MyHC decreased at 1 week post-recession (in both layers P < 0.01) but returned to preoperative levels by 4 weeks (in both layers P = 1). Embryonic MyHC remained stable (P = 0.239) or increased (in the GL post-recession and in the orbital layer (OL) post-resection, both P < 0.001) at 1 week postoperatively, except in the GL post-resection. It had returned (in the GL post-recession, P = 0.952; in the GL post-resection, P = 0.574) or nearly returned (in the OL post-resection, P = 0.038) to preoperative levels in both layers by 4 weeks. Activated SCs in 1-month-old rabbits continuously increased post-surgery (all P < 0.05), except in the OL post-resection. In 3-month-old rabbits, SCs remained stable at 1 week but decreased by 4 weeks post-surgery (all P < 0.01), except in the OL post-resection. Centrally nucleated myofibers were more prevalent in 1-month-old rabbits by 4 weeks postoperatively. Conclusions: One-month-old rabbits displayed longer postoperative remodeling and greater plasticity in EOMs than 3-month-old rabbits. The difference in postoperative remodeling may impact strabismus surgery outcomes in patients of different developmental stages.
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