Evidence map›Paper›PMID 40042764›Full record

ArticlePituitary2025

Identifying research priorities for pituitary adenoma surgery: an international Delphi consensus statement.

Nicola Newall, Alexandra Valetopoulou, Danyal Z Khan, Anouk Borg, Pierre M G Bouloux, Fion Bremner, Michael Buchfelder, Simon Cudlip, Neil Dorward, William M Drake and 26 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Nicola NewallNational Hospital for Neurology and Neurosurgery, London, UK. n.nicola@ucl.ac.uk.
Alexandra ValetopoulouNational Hospital for Neurology and Neurosurgery, London, UK.
Danyal Z KhanNational Hospital for Neurology and Neurosurgery, London, UK.
Anouk BorgNational Hospital for Neurology and Neurosurgery, London, UK.
Pierre M G BoulouxDepartment of Endocrinology, University College London Hospitals NHS Foundation Trust, London, UK.
Fion BremnerNational Hospital for Neurology and Neurosurgery, London, UK.
Michael BuchfelderUniversity Hospital Erlangen, Erlangen, Germany.
Simon CudlipOxford University Hospitals NHS Foundation Trust, Oxford, UK.
Neil DorwardNational Hospital for Neurology and Neurosurgery, London, UK.
William M DrakeBarts and the London School of Medicine, Queen Mary University of London, London, UK.
Juan C Fernandez-MirandaStanford University School of Medicine, 213 Quarry Road, Palo Alto, USA.
Maria FleseriuOregon Health & Science University, Portland, USA.
Mathew GeltzeilerOregon Health & Science University, Portland, USA.
Joy GinnThe Pituitary Foundation, Bristol, UK.
Mark GurnellCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Steve HarrisThe Pituitary Foundation, Bristol, UK.
Zane JaunmuktaneNational Hospital for Neurology and Neurosurgery, London, UK.
Márta KorbonitsBarts and the London School of Medicine, Queen Mary University of London, London, UK.
Michael KosminDepartment of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
Olympia KoulouriCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Hugo Layard HorsfallNational Hospital for Neurology and Neurosurgery, London, UK.
Adam N MamelakCedars-Sinai Medical Center, Los Angeles, CA, USA.
Richard MannionCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Pat McBrideThe Pituitary Foundation, Bristol, UK.
Ann I McCormackSt Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.
Shlomo MelmedCedars-Sinai Medical Center, Los Angeles, CA, USA.
Katherine A MiszkielNational Hospital for Neurology and Neurosurgery, London, UK.
Gerald RaverotDepartment of Endocrinology, French Reference Center for Rare Pituitary Diseases HYPO, Hospices Civils de Lyon, 69002, Lyon, France.
Thomas SantariusCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Theodore H Schwartz, NY, USA.
Inma SerranoNational Hospital for Neurology and Neurosurgery, London, UK.
Gabriel ZadaKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Stephanie E Baldeweg *Division of Medicine, Department of Experimental and Translational Medicine, University College London, London, UK.
Angelos G Kolias *Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Hani J Marcus *National Hospital for Neurology and Neurosurgery, London, UK.
PitCop Collaborative

Funding

Wellcome Trust
6 · The paper itself

Abstract

purposePituitary surgery is the mainstay treatment for most pituitary adenomas, but many questions remain about perioperative and long-term management and outcomes. This study aimed to identify the most pressing research priorities in pituitary surgery with input from patients, caregivers, and healthcare professionals.

methodsAn initial survey of patients, caregivers, and healthcare professionals assembled priorities related to preoperative care, surgical techniques, and postoperative management in pituitary surgery. Priorities were thematically grouped into summary priorities, and those answered by existing evidence were omitted following a literature review. An interim survey asked patients, caregivers, and healthcare professionals to select their top 10 priorities from the remaining list. The highest-ranked priorities advanced to a consensus meeting, where the top 10 questions were prioritized.

resultsIn the initial survey, 147 participants-60.5% of whom were patients, caregivers, or patient support group representatives-submitted 785 priorities, which were then condensed into 52 summary priorities. After a literature review, 33 unanswered priorities were included in the interim survey, completed by 155 respondents, of whom 54.2% were patients, caregivers, or patient support group representatives. The top-ranked priorities were discussed by 14 participants (7 patients and 7 healthcare professionals) during a consensus meeting. The top 10 priorities covered a variety of themes including enhancing diagnosis and management of pituitary adenomas, advancing surgical techniques and technologies, optimizing the prediction of outcomes and complications, and improving patient support and follow-up.

conclusionsThe top 10 research priorities in pituitary surgery aim to align researchers and direct funding in order to maximize impact and champion patient representation.

Indexed as

AdenomaPituitary NeoplasmsAdultConsensus Statements as TopicDelphi TechniqueFemaleHumansMaleMiddle AgedSurveys and QuestionnairesPituitary surgeryPriority settingResearch priorities

Identifiers

PMID40042764
PMCPMC11882698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.