Evidence map›Paper›PMID 40042666›Full record

ArticlePituitary2025

Outcomes of endoscopic endonasal surgery for pediatric craniopharyngioma with a focus on morphological preservation of the pituitary stalk and endocrine functions.

Hiroyoshi Kino, Hiroyoshi Akutsu, Shuho Tanaka, Atsushi Iwabuchi, Takuma Hara, Yusuke Morinaga, Takeshi Hongo, Kotaro Osawa, Shingo Takano, Eiichi Ishikawa

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiroyoshi KinoDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Hiroyoshi AkutsuDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan. h-akutsu887@dokkyomed.ac.jp.
Shuho TanakaDepartment of Otolaryngology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Atsushi IwabuchiDepartment of Pediatrics, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Takuma HaraDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Yusuke MorinagaDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Takeshi HongoDepartment of Neurosurgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.
Kotaro OsawaDepartment of Otolaryngology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Shingo TakanoDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Eiichi IshikawaDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePreservation of endocrine function in pediatric patients with craniopharyngioma is crucial. However, few reports of endoscopic endonasal surgery (EES) for pediatric craniopharyngiomas with intending endocrine function preservation exist. This study aimed to identify the outcomes of EES with intending preservation of pituitary stalk in pediatric patients with craniopharyngioma.

methodsData from 22 pediatric patients with craniopharyngioma who underwent 35 EESs between 2011 and 2022 were retrospectively assessed. The tumor location (infradiaphragmatic [ID] or supradiaphragmatic [SD]) and endocrine functions were evaluated. The patients were divided into two groups: those with preoperatively preserved some endocrine function (Group P) and already completely lost endocrine function (Group ACL). Morphological preservation of the pituitary stalk (MPPS) and postoperative endocrine functional outcomes were analyzed only in the cases of Group P. Tumor recurrence was evaluated in all patients.

resultsIn the 35 EESs, the tumors were ID in 17 cases and SD in 18. Twenty-five cases were included in Group P and 10 in Group ACL. In Group P, MPPS was achieved in 18 (72%) cases, and postoperative preservation of some endocrine function was achieved in 14 (77.8%) of the MPPS cases. ID tumor (P < 0.001) and intraoperative MPPS (P < 0.001) were associated with postoperative preservation of some endocrine function. Intraoperative MPPS (P = 0.044) was a significantly associated risk factor for tumor recurrence.

conclusionsIn EES for pediatric craniopharyngiomas, postoperative preservation of some endocrine function is achievable in ID tumors with MPPS. Therefore, preservation of endocrine function should be attempted in cases of ID tumors. However, clinicians should be aware that MPPS increases the risk of tumor recurrence.

Indexed as

CraniopharyngiomaEndoscopyNasal Surgical ProceduresOrgan Sparing TreatmentsPituitary NeoplasmsAdolescentChildChild, PreschoolFemaleHormonesHumansInfantMalePituitary GlandPostoperative ComplicationsRetrospective StudiesHormonesEndocrine functionEndoscopic endonasal surgeryPediatric craniopharyngiomaPituitary stalkVisual function

Identifiers

PMID40042666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.