Evidence map›Paper›PMID 40042560›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

2-Aminomethyl phenothiazine, its alkyl and triphenylphosphonium derivatives suppress erastin-induced ferroptosis in BT-474 cells but exhibit distinct cytotoxic activities.

Mikhail V Dubinin, Anna I Ilzorkina, Darya A Nedopekina, Natalia V Mikina, Natalia V Belosludtseva, Rezeda R Khalitova, Jun Moni Kalita, Eldar V Davletshin, Anna Yu Spivak, Damiki Laloo and 1 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mikhail V DubininMari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia. dubinin_mv@marsu.ru.
Anna I IlzorkinaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow region, 142290, Russia.
Darya A NedopekinaInstitute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospekt Oktyabrya 141, Ufa, 450075, Russia.
Natalia V MikinaMari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.
Natalia V BelosludtsevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow region, 142290, Russia.
Rezeda R KhalitovaInstitute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospekt Oktyabrya 141, Ufa, 450075, Russia.
Jun Moni KalitaGirijananda Chowdhury University, Guwahati, 781017, Assam, India.
Eldar V DavletshinInstitute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospekt Oktyabrya 141, Ufa, 450075, Russia.
Anna Yu SpivakInstitute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospekt Oktyabrya 141, Ufa, 450075, Russia.
Damiki LalooGirijananda Chowdhury University, Guwahati, 781017, Assam, India.
Konstantin N BelosludtsevMari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation FMRS-2025-0033
6 · The paper itself

Abstract

This work demonstrates the antiferroptotic and cytotoxic effects of 2-aminomethyl phenothiazine (PTZ-NH

Indexed as

Antineoplastic AgentsFerroptosisOrganophosphorus CompoundsPhenothiazinesPiperazinesAnimalsAntioxidantsCell Line, TumorCell SurvivalDose-Response Relationship, DrugHumansMaleMitochondria, LiverRatsReactive Oxygen SpeciesAntineoplastic AgentsAntioxidantserastinOrganophosphorus CompoundsPhenothiazinesPiperazinesReactive Oxygen SpeciestriphenylphosphoniumCytotoxicityErastinFerroptosisMitochondriaPhenothiazine derivativesROS

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.