Evidence map›Paper›PMID 40042433›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Scam susceptibility is associated with a markedly accelerated onset of Alzheimer's disease dementia.

Patricia A Boyle, Tianhao Wang, Gary Mottola, Chris Stewart, Robert S Wilson, David A Bennett, Lei Yu

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Decomposing trust-related decision making: dimensionality and predictability of phishing susceptibility in an adult lifespan sample.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  3. Article
  4. Scam susceptibility is associated with a markedly accelerated onset of Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Patricia A BoyleRush University Medical Center, Rush Alzheimer's Disease Center, Chicago, Illinois, USA.ORCID 0000-0002-3245-3456
Tianhao WangRush University Medical Center, Rush Alzheimer's Disease Center, Chicago, Illinois, USA.
Gary MottolaFINRA Investor Education Foundation, Washington, District of Columbia, USA.
Chris StewartDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Robert S WilsonRush University Medical Center, Rush Alzheimer's Disease Center, Chicago, Illinois, USA.
David A BennettRush University Medical Center, Rush Alzheimer's Disease Center, Chicago, Illinois, USA.
Lei YuRush University Medical Center, Rush Alzheimer's Disease Center, Chicago, Illinois, USA.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Characterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8M
Epidemiologic Study of Impaired Decision-Making in Preclinical Alzheimer's DiseasR01AG033678 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BOYLE, PATRICIA A · 2009 to 2025
$7.8M
Illinois Department of Public HealthNIA NIH HHS R01 AG017917NIA NIH HHS R01 AG033678NIA NIH HHS R01 AG034374NIA NIH HHS R01AG17917NIA NIH HHS R01AG33678NIA NIH HHS R01AG34374
6 · The paper itself

Abstract

introductionThe association of scam susceptibility with the timing of Alzheimer's disease (AD) dementia onset is unknown.

methodsOne thousand ninety-two older adults without dementia underwent assessments of scam susceptibility and annual clinical evaluations to document incident AD dementia. Accelerated failure time models examined the relation of scam susceptibility with dementia onset.

resultsDuring a mean of 5 years of follow-up (standard deviation = 3.1), 188 individuals (17%) were diagnosed with incident AD dementia. A higher level of scam susceptibility was associated with a considerably earlier dementia onset ( DISCUSSION: Scam susceptibility is associated with a markedly earlier onset of AD dementia. Assessment of susceptibility may facilitate early identification of individuals at risk of developing dementia. HIGHLIGHTS: We examined whether scam susceptibility among older adults is associated with an accelerated onset of Alzheimer's disease dementia. Participants came from a large ongoing cohort study of aging. Scam susceptibility was assessed using a validated measure. Scam susceptibility was associated with a marked acceleration in dementia onset. Assessment of susceptibility may facilitate early identification of dementia.

Indexed as

Alzheimer DiseaseAgedAged, 80 and overAge of OnsetDisease SusceptibilityFemaleHumansMaleAlzheimer's diseasecognitive agingdementiafraudscam

Identifiers

PMID40042433
PMCPMC11881619

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.