Evidence map›Paper›PMID 40042383›Full record

ArticleeLife2025

Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity.

Jacob W Klemm, Chloe Van Hazel, Robin E Harris

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jacob W KlemmArizona State University, Tempe, United States.ORCID https://orcid.org/0000-0002-1414-5089
Chloe Van HazelArizona State University, Tempe, United States.ORCID https://orcid.org/0009-0007-6175-2678
Robin E HarrisArizona State University, Tempe, United States.ORCID https://orcid.org/0000-0001-6945-6741

Funding

Understanding Necrosis-Induced Tissue RegenerationR01GM147615 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Robin Harris · 2022 to 2026
$1.6M
The regenerative response to tissue necrosisR21HD102765 · NICHD · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI HARRIS, ROBIN · 2020 to 2021
$409k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R21HD102765NICHD NIH HHS R21 HD102765NIGMS NIH HHS R01 GM147615NIGMS NIH HHS R01GM147615
6 · The paper itself

Abstract

Tissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue - an essential consideration when developing effective methods to treat such injuries - has been limited by a lack of robust genetically tractable models. Our lab previously established a method to study necrosis-induced regeneration in the

Indexed as

CaspasesDrosophila melanogasterDrosophila ProteinsNecrosisRegenerationWings, AnimalAnimalsApoptosisCell ProliferationImaginal DiscsSignal TransductionCaspasesdronc protein, DrosophilaDrosophila Proteinscaspasecell deathD. melanogastergeneticsnecrosisregenerationregenerative medicinestem cells

Identifiers

PMID40042383
PMCPMC11882144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.