ArticleAddiction biology2025
Altered Functional Connectivity Dynamics Serving Cognitive Flexibility in Regular Cannabis Users.
Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Hippocampal and cortical oscillatory dynamics support semantic processing and performance.Communications biology · 2026Article
- Regular cannabis use modulates gamma functional connectivity with V1 during visual processing.NeuroImage · 2025Article
- zBMI scales with multispectral alterations in the neural oscillatory dynamics serving verbal working memory in youth.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Despite its widespread use and popularity, cannabis is known to impact higher order cognitive processes such as attention and executive function. However, far less is known about the impact of chronic cannabis use on cognitive flexibility, a component of executive function, and this is especially true for the underlying functional connectivity dynamics. To address this, we enrolled 25 chronic cannabis users and 30 demographically matched non-users who completed an interview probing current and past substance use, a urinalysis to confirm self-reported substance use and a task-switch cognitive paradigm during magnetoencephalography (MEG). Time-frequency windows of interest were identified using a data-driven statistical approach, and spectrally specific neural oscillatory responses were imaged using a beamformer. The resulting maps were grand-averaged across all participants and conditions, and the peak voxels in these maps of neural oscillatory activity were used as seeds to compute connectivity using a whole-brain cortical-coherence approach. Whole-brain neural switch cost connectivity maps were then computed by subtracting the connectivity map for the no-switch condition from that of the switch condition per participant. These switch cost functional connectivity maps were then correlated with the behavioural switch cost per group and probed for group differences in the neuro-behavioural associations. Our behavioural results indicated that all participants had slower reaction times during switch compared to no-switch trials. Regarding the MEG data, cannabis users exhibited altered associations between functional connectivity switch costs and behavioural switch costs along pathways connecting visual cortices and regions in the ventral attention network, within the theta, alpha and gamma frequency ranges. These results indicate modified multispectral associations between functional connectivity and behavioural switch costs among visual cortices and key brain regions underlying executive function in cannabis users.
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Registered trials
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