Evidence map›Paper›PMID 40042245›Full record

ArticleeLife2025

Post-ejaculatory inhibition of female sexual drive via heterogeneous neuronal ensembles in the medial preoptic area.

Kentaro K Ishii, Koichi Hashikawa, Jane Chea, Shihan Yin, Rebecca Erin Fox, Suyang Kan, Meha Shah, Zhe Charles Zhou, Jovana Navarrete, Alexandria D Murry and 3 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kentaro K IshiiCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-7956-0806
Koichi HashikawaCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Jane CheaCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Shihan YinCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Rebecca Erin FoxCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Suyang KanCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Meha ShahCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Zhe Charles ZhouCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Jovana NavarreteCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Alexandria D MurryCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Eric R SzelenyiCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Sam A GoldenCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
Garret D StuberCenter for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-1730-4855

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Neural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5M
Lateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0M
Transcriptional, functional, and circuit profiling at single cell resolution of neuronal ensembles engaged by heroin relapseR01DA054317 · NIDA · UNIVERSITY OF WASHINGTON · PI FERGUSON, SUSAN MARIE, STUBER, GARRET D · 2021 to 2025
$2.7M
Midbrain Neural Circuit Elements That Underlie Cue-Reward AssociationsR01DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2012 to 2016
$1.6M
NIDA NIH HHS DA032750NIDA NIH HHS DA038168NIDA NIH HHS DA048736NIDA NIH HHS DA054317NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA032750NIDA NIH HHS R01 DA038168NIDA NIH HHS R01 DA054317NIDA NIH HHS R37 DA032750
6 · The paper itself

Abstract

Male ejaculation acutely suppresses sexual motivation in male mice. In contrast, relatively little is known about how male ejaculation affects sexual motivation and sexual behavior in female mice. How the brain responds to the completion of mating is also unclear. Here, by using a self-paced mating assay, we first demonstrate that female mice show decreased sexual motivation acutely after experiencing male ejaculation. By using brain-wide analysis of activity-dependent labeling, we next pin-pointed the medial preoptic area as a brain region strongly activated during the post-ejaculatory period. Furthermore, using freely moving

Indexed as

EjaculationNeuronsPreoptic AreaSexual Behavior, AnimalAnimalsFemaleMaleMiceMice, Inbred C57BLMotivationcalcium imaginghypothalamusmouseneurosciencesexual behaviorsocial behaviortissue clearing

Identifiers

PMID40042245
PMCPMC11882143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.