Evidence map›Paper›PMID 40042134›Full record

ArticlePediatric pulmonology2025

"Evaluation of Different Inspiratory Efforts in a Pediatric Model of Healthy Lung and Pediatric Acute Respiratory Distress Syndrome During Optimized Pressure Support Ventilation and Proportional Assist Ventilation Plus (PAV+): A Bench Study.

G Spinazzola, G Ferrone, R Costa, O Festa, M Piastra, G Bello, M F Amato, M Rossi, G Conti

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06998927 (Proportional Assist Ventilation Plus and Estimation of Respiratory Effort in Critically Ill Patients During the Transition to Spontaneous Ventilation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06998927 active not recruitingnot on this map

Proportional Assist Ventilation Plus and Estimation of Respiratory Effort in Critically Ill Patients During the Transition to Spontaneous Ventilation: A Prospective Cohort Study

TypeobservationalSponsorArgentinian Intensive Care SocietyRan2024 to 2025Enrolled35ConditionsRespiratory Effort, Proportional Assist Ventilation, Work of BreathingArmsApplication of Proportional Assist Ventilation Plus (PAV+) at three support levels (20%, 50%, 70%) to assess ventilator-displayed work of breathing and its correlation with physiologic measures.
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

G SpinazzolaDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0001-8055-5142
G FerroneDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
R CostaDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
O FestaDepartment of Anesthesia and Intensive Care, Hospital General Sant Joan de Deu Sant Boi, Barcelona, Spain.
M PiastraDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
G BelloDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
M F AmatoDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
M RossiDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
G ContiDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-8566-9365

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

introductionWhile proportional ventilator modes have gained popularity in adult patients' ventilatory management, Proportional Assist Ventilation (PAV+) use in pediatric patients with Pediatric Acute Respiratory Distress Syndrome (PARDS) remains unexplored. This study aims to evaluate the effects of optimized PSV and PAV+ on patient-ventilator interaction and respiratory pattern in two pediatric simulated lung models.

methodsThe study utilized an active lung simulator to replicate two pediatric lung models: one healthy and one with mild PARDS. Each model was ventilated using PAV+ and optimized PSV at four different levels, assessing simulated patient-ventilator interaction and mechanical response to increase inspiratory effort.

resultsIn terms of simulated patient-ventilator interaction, in a healthy and mild PARDS lung model and all setting tested, the optimized PSV presented the better patient-ventilator interaction with the shortest values of Inspiratory trigger delay (Delay

conclusionsIn a healthy lung model, optimized PSV allows optimal simulated patient-ventilator interaction and assistance levels compared to PAV+. On the contrary, in a simulated lung with mild PARDS, PAV+ appears as a valid alternative to PSV, especially under conditions of intense inspiratory effort and high assistance levels.

Indexed as

InhalationInteractive Ventilatory SupportLungPositive-Pressure RespirationRespiratory Distress SyndromeChildHumansModels, Biologicalacute respiratory failuremechanical ventilationpatient‐ventilator interactionproportional ventilationrespiratory distress

Identifiers

PMID40042134
PMCPMC11881212

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.