Evidence map›Paper›PMID 40042059›Full record

ReviewAllergy2025

Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps.

Mu Xian, Bing Yan, Xicheng Song, Jianjun Chen, Jun Tang, Yan Jiang, Lijia Wan, Wen Liu, Jinmei Xue, Zhiwei Cao and 36 more

2 registry-linked trialsAbstract readConsensus StatementReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07200336 phase4not yet recruitingnot on this map

Efficacy of Anti-IL-5 Therapy Combined With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery in Patients With CRSwNP: A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorEye & ENT Hospital of Fudan UniversityRan2025 to 2031Enrolled360ConditionsChronic Rhinosinusitis With Nasal Polyps (CRSwNP)ArmsMepolizumab, Simple Polypectomy, Extended Endoscopic Sinus Surgery
NCT07616609 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Placebo-Controlled, Double-Blinded Trial of Preoperative Stapokibart With Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps

TypeinterventionalSponsorBeijing Tongren HospitalRan2026 to 2028Enrolled48ConditionsChronic Rhinosinusitis With Nasal Polyps (CRSwNP)ArmsStapokibart, Matched placebo
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Comprehensive immunological and molecular analysis revealed inflammation-related diagnostic signatures in chronic rhinosinusitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  7. [Indications of biological treatment in patients with chronic rhinosinusitis with nasal polyps].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Article
  8. Review
  9. Review
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Mu XianDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-4153-6314
Bing YanDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Xicheng SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
Jianjun ChenDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jun TangOtolaryngology Department, The First People's Hospital, Foshan, Guangdong, China.
Yan JiangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Lijia WanDepartment of Otorhinolaryngology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
Wen LiuDepartment of Otorhinolaryngology, Zibo Central Hospital, Zibo, Shandong, China.
Jinmei XueDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Zhiwei CaoDepartment of Otolaryngology-Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Yafeng YuDepartment of Otolaryngology Head & Neck Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiangli YangDepartment of Otolaryngology Head and Neck Surgery, Tianjin Union Medical Center, Tianjin, China.
Li ShiDepartment of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.
Guangke WangDepartment of Otolaryngology, Head and Neck Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yu XuDepartment of Rhinology and Allergy, Otolaryngology-Head and Neck Surgery Centre, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0001-7751-6345
Yucheng YangDepartment of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-2413-2935
Jing YeDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID https://orcid.org/0000-0002-1737-4573
Luyun JiangDepartment of Otorhinolaryngology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Fang QuanDepartment of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China.
Guolin TanDepartment of Otorhinolaryngology, Head and Neck Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0003-0703-8151
Feng LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, West China Hospital Sichuan University, Chengdu, Sichuan, China.
Zhendong XuE.N.T. Department, Baotou Central Hospital, Baotou, Inner Mongolia Autonomous Region, China.
Xiaowen ZhangDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0001-5255-8610
Jiping LiDepartment of Otolaryngology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lizhong SuDepartment of Otolaryngology, Centre of Otolaryngology Head and Neck Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Zhejiang, Hangzhou, China.
Yi YangOtolaryngology Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Jiangang FanDepartment of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Gang HeDepartment of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Li ZhuDepartment of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, China.
Xiangdong WangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Ming WangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Shen ShenDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Jian LiDepartment of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Huabin LiAllergy Center, Department of Otolaryngology, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2477-2879
Xin WeiDepartment of Otorhinolaryngology Head and Neck Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Hongmeng YuENT Institute and Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Zheng LiuDepartment of Otolaryngology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-4168-6702
Ruixia MaThe Department of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Yinchuan, Yinchuan, Ningxia, China.
Huanhai LiuDepartment of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai, China.
Jianfeng LiuDepartment of Otolaryngology-Head and Neck Surgery, China-Japan Friendship Hospital, Beijing, China.
Wei LvDepartment of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qintai YangDepartment of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Dongdong ZhuDepartment of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-8495-5626
Lei ChengDepartment of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-6541-7702
Chengshuo WangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-0646-5135
Luo ZhangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0910-9884

Funding

Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes, Beijing Municipal Health Commission JYY2023-1Beijing Municipal Science and Technology Project Z211100002921057Beijing Municipal Science and Technology Project Z221100007422009Capital's Funds for Health Improvement and Research CFH2022-1-1091National Key R&D Program of China 2022YFC2504100National Natural Science Foundation of China 82025010National Natural Science Foundation of China 82171111National Natural Science Foundation of China 82371115National Natural Science Foundation of China 82471135
6 · The paper itself

Abstract

Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of registered biologics for CRSwNP treatment in China, the country is experiencing rapid development in this field. It is imperative to standardize the application of biologic agents in CRSwNP management in preparation for their future integration into the CRSwNP care pathway. The Rhinology Group, Chinese Society of Otorhinolaryngology-Head and Neck Surgery; the Rhinology Group, Chinese Medical Doctor Association of Otorhinolaryngology-Head and Neck Surgery; and the Nasal and Ocular Allergy Group, Chinese Society of Allergy have convened an expert panel consisting of principal investigators experienced in clinical trials of biologic treatment for CRSwNP. This expert panel was assembled to discuss the application of biologic agents in patients with CRSwNP in China. Additionally, the latest findings on the pathogenesis of CRSwNP, mechanisms of biologic agents, and efficacy and safety of biologic treatment in patients with CRSwNP were reviewed, with a special emphasis on research evidence from China. The expert panel reached a consensus on several critical issues, including criteria for the prescription, treatment course, and efficacy evaluation from a Chinese perspective. This position paper aims to guide Chinese physicians in the use of biologic agents for patients with CRSwNP. As our experience with biologic treatment continues to grow, this position paper will be further updated.

Indexed as

Biological ProductsBiological TherapyNasal PolypsRhinitisSinusitisChinaChronic DiseaseDisease ManagementHumansRhinosinusitisTreatment OutcomeBiological ProductsbiologicsChinachronic rhinosinusitis with nasal polypsmonoclonal antibodytreatment

Identifiers

PMID40042059
PMCPMC12105070

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.