Evidence map›Paper›PMID 40041895›Full record

ArticleActa pharmaceutica Sinica. B2025

Caffeic acid-vanadium nanozymes treat skin flap ischemia-reperfusion injury through macrophage reprogramming and the upregulation of X-linked inhibitors of apoptotic proteins.

Xinyu Zhao, Jie Shan, Hanying Qian, Xu Jin, Yiwei Sun, Jianghao Xing, Qingrong Li, Xu-Lin Chen, Xianwen Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyu ZhaoDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Jie ShanDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Hanying QianDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Xu JinDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Yiwei SunSchool of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
Jianghao XingSchool of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
Qingrong LiSchool of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
Xu-Lin ChenDepartment of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Xianwen WangSchool of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia-reperfusion (I/R) injury following skin flap transplantation is a critical factor leading to flap necrosis and transplant failure. Antagonizing inflammatory responses and oxidative stress are regarded as crucial targets for mitigating reperfusion injury and enhancing flap survival. In this study, caffeic acid-vanadium metal polyphenol nanoparticles (CA-V NPs) were prepared for the treatment of skin flap ischemia and reperfusion. This study was conducted using a one-step method to prepare new types of CA-V NPs with uniform sizes and stable structures.

Indexed as

ApoptosisCaffeic acid-vanadiumChemokinesInflammationIschemia-reperfusionNanozymesOxidative stressSkin flap

Identifiers

PMID40041895
PMCPMC11873662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.