Trial reportActa pharmaceutica Sinica. B2025
Real-world efficacy and safety of azvudine in hospitalized older patients with COVID-19 during the omicron wave in China: A retrospective cohort study.
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Trial report in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
55 authors.
Yuanchao ZhuDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Fei ZhaoDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Yubing ZhuDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Xingang LiDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Deshi DongDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Bolin ZhuDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Jianchun LiDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Xin HuDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Zinan ZhaoDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Wenfeng XuDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Yang JvDepartment of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Dandan WangDepartment of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Yingming ZhengDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Yiwen DongDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Lu LiDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Shilei YangDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Zhiyuan TengDepartment of Pharmacy, the Second People's Hospital of Guiyang (Jinyang Hospital)/the Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang 550023, China.
Ling LuDepartment of Pharmacy, the Second People's Hospital of Guiyang (Jinyang Hospital)/the Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang 550023, China.
Jingwei ZhuDepartment of Pharmacy, the Second People's Hospital of Guiyang (Jinyang Hospital)/the Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang 550023, China.
Linzhe DuDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Yunxin LiuDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Lechuan JiaDepartment of Pharmacy, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Qiujv ZhangDepartment of Pharmacy, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Hui MaDepartment of Pharmacy, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Ana ZhaoDepartment of Pharmacy, Changchun Central Hospital, Changchun 130051, China.
Hongliu JiangDepartment of Pharmacy, Changchun Central Hospital, Changchun 130051, China.
Xin XuDepartment of Pharmacy, Affiliated Hospital of Nantong University, Nantong 226001, China.
Jinli WangDepartment of Pharmacy, Affiliated Hospital of Nantong University, Nantong 226001, China.
Xuping QianDepartment of Pharmacy, Affiliated Hospital of Nantong University, Nantong 226001, China.
Wei ZhangDepartment of Pharmacy, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Tingting ZhengDepartment of Pharmacy, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Chunxia YangDepartment of Pharmacy, Beijing Shunyi Hospital, Beijing 101300, China.
Xuguang ChenDepartment of Pharmacy, Beijing Shunyi Hospital, Beijing 101300, China.
Kun LiuDepartment of Pharmacy, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
Huanhuan JiangDepartment of Pharmacy, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
Dongxiang QuDepartment of Pharmacy, the First Hospital of Qiqihar, Qiqihar 161005, China.
Jia SongDepartment of Pharmacy, the First Hospital of Qiqihar, Qiqihar 161005, China.
Hua ChengDepartment of Pharmacy, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.
Wenfang SunDepartment of Pharmacy, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.
Hanqiu ZhanDepartment of Pharmacy, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Xiao LiDepartment of Pharmacy, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Yafeng WangDepartment of Pharmacy, Qinghai Provincial People's Hospital, Xining 810007, China.
Aixia WangDepartment of Pharmacy, Qinghai Provincial People's Hospital, Xining 810007, China.
Li LiuDepartment of Pharmacy, the Fifth People's Hospital of Ningxia, Shizuishan 753000, China.
Lihua YangDepartment of Pharmacy, the Fifth People's Hospital of Ningxia, Shizuishan 753000, China.
Nan ZhangDepartment of Pharmacy, Beijing Chuiyangliu Hospital, Beijing 100022, China.
Shumin ChenDepartment of Pharmacy, Fuxing Hospital, Capital Medical University, Beijing 100038, China.
Jingjing MaDepartment of Pharmacy, the Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou 215000, China.
Wei LiuDepartment of Pharmacy, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
Xiaoxiang DuDepartment of Pharmacy, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Meiqin ZhengDepartment of Pharmacy, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Liyan WanDepartment of Pharmacy, the First Hospital of Tsinghua University, Beijing 100016, China.
Guangqing DuDepartment of Pharmacy, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing 100144, China.
Hangmei LiuDepartment of Pharmacy, Emergency General Hospital, Beijing 100028, China.
Pengfei JinDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Debates persist regarding the efficacy and safety of azvudine, particularly its real-world outcomes. This study involved patients aged ≥60 years who were admitted to 25 hospitals in mainland China with confirmed SARS-CoV-2 infection between December 1, 2022, and February 28, 2023. Efficacy outcomes were all-cause mortality during hospitalization, the proportion of patients discharged with recovery, time to nucleic acid-negative conversion (
Indexed as
AzvudineCOVID-19EfficacyOlderOmicronSafetySARS-CoV-2
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