Evidence map›Paper›PMID 40041857›Full record

ArticlePatterns (New York, N.Y.)2025

SplitFusion enables ultrasensitive gene fusion detection and reveals fusion variant-associated tumor heterogeneity.

Weiwei Bian, Baifeng Zhang, Zhengbo Song, Binyamin A Knisbacher, Yee Man Chan, Chloe Bao, Chunwei Xu, Wenxian Wang, Athena Hoi Yee Chu, Chenyu Lu and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Patterns (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Weiwei BianMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Baifeng ZhangMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Zhengbo SongDepartment of Clinical Trial, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
Binyamin A KnisbacherBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yee Man ChanMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Chloe BaoMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Chunwei XuDepartment of Clinical Trial, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
Wenxian WangDepartment of Clinical Trial, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
Athena Hoi Yee ChuMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Chenyu LuDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, China.
Hongxian WangDepartment of Neurosurgery, Shanghai Changhai Hospital, Shanghai 200003, China.
Siyu BaoMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Zhenyu GongDepartment of Neurosurgery, Shanghai Changhai Hospital, Shanghai 200003, China.
Hoi Yee KeungMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Zi-Ying Maggie ChowMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.
Yiping ZhangDepartment of Clinical Trial, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
Wah CheukDepartment of Pathology, Queen Elizabeth Hospital, Hong Kong SAR, China.
Gad GetzBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Valentina NardiDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Mengsu YangDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, China.
William Chi Shing ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China.
Jian WangInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China.
Juxiang ChenDepartment of Neurosurgery, Shanghai Changhai Hospital, Shanghai 200003, China.
Zongli ZhengMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene fusions are common cancer drivers and therapeutic targets, but clinical-grade open-source bioinformatic tools are lacking. Here, we introduce a fusion detection method named SplitFusion, which is fast by leveraging Burrows-Wheeler Aligner-maximal exact match (BWA-MEM) split alignments, can detect cryptic splice-site fusions (e.g.,

Indexed as

ALK variantAMPARv7DUX4FFPE samplesfusion detection toolRNA-seqROS1TCGAtumor heterogeneity

Identifiers

PMID40041857
PMCPMC11873004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.