ArticleHealth science reports2025
Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Response to Commentary on "Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis".Health science reports · 2025Article
- Sedentary Lifestyle, Physical Activity, and Healthy Digital Media Use of Filipino Adolescents: Review and Policy Insights.Health science reports · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these associations with GERD. Methods: Genetic instruments from the UK Biobank and other consortia were utilized to assess the causal relationship between LSBs, PAs, and GERD. Causal analyses employed inverse variance weighted (IVW), weighted-median (WM), and MR-Egger regression. Sensitivity analyses included Cochran's Results: Genetically predicted leisure television (TV) watching (OR = 2.29, 95% CI 2.12-2.48; Conclusions: Leisure TV watching and self-reported MPA are associated with an higher risk of GERD, whereas leisure computer use and accelerometer-measured fractional acceleration > 425 milligravities may serve as protective factors against GERD. These findings highlight the necessity of differentiating various LSBs and PAs in GERD research.
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