ReviewBiologics : targets & therapy2025
Unraveling Tumor-to-Tumor Metastasis: Insights into Pathogenesis, Diagnostic Challenges, and Treatment Modalities.
Review in Biologics : targets & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Metastasis of lung carcinoma in a pheochromocytoma.JCEM case reports · 2026Article
- Tumour-to-tumour metastasis: head and neck squamous cell carcinoma to enchondroma.Skeletal radiology · 2026Article
- Tumor-to-tumor metastasis of breast carcinoma to clear cell renal cell carcinoma: a rare case with a review of the literature.CEN case reports · 2026Review
- Selective Tumor-to-Tumor Metastasis of the LCNEC Component of a Combined Lung Carcinoma to Clear Cell Renal Cell Carcinoma Despite a Concurrent Meningioma.IJU case reports · 2026Article
- Article
- Synchronous tumor-to-tumor metastasis of breast carcinoma to intracranial meningioma: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- First pathologically confirmed case of concurrent primary renal cell carcinoma and metastatic lung adenocarcinoma in the same kidney.Frontiers in oncology · 2026Article
- Tumor-to-Tumor Metastasis: Breast Cancer Metastasizing to EGFR Exon 19-Mutated Lung Adenocarcinoma with Long-Term Disease-Free Survival.Biologics : targets & therapy · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor-to-tumor metastasis (TTM) is defined as the metastasis of one distinct malignancy to another independent tumor without directly extending into the substance of a histologically distinct and separate tumor. TTM is an extremely rare phenomenon that constitutes a very small percentage of all tumor metastases. The detailed histogenic mechanisms of TTM remain unclear. TTM is easily confused with composite tumors and synchronous tumors. Due to the rarity and complexity of the disease, it presents significant challenges in providing accurate diagnoses and appropriate treatment options. The exploration of TTM not only provides an in-depth understanding of the metastasis process, but also has significant implications for the management and treatment of patients with multiple primary malignant tumors, underscoring the necessity of comprehensive diagnostic and treatment strategies. The purpose of this review is to increase awareness of tumor-to-tumor metastasis, with a focus on pathogenesis, diagnosis, and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.