Evidence map›Paper›PMID 40041662›Full record

ArticleEJHaem2025

Haploidentical Allogeneic Stem Cell Transplantation as a Superior Alternative for Patients With Mismatch Donors-A Single Center Experience in 152 Patients.

Paul Jäger, Benno Biermann, Nora Liebers, Felicitas Schulz, Ben-Niklas Baermann, Sören Twarock, Stefanie Geyh, Kathrin Nachtkamp, Patrick Tressin, Annika Kasprzak and 6 more

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Paul JägerDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.ORCID https://orcid.org/0000-0001-9250-2064
Benno BiermannDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Nora LiebersDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Felicitas SchulzDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Ben-Niklas BaermannDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.ORCID https://orcid.org/0009-0000-1699-9478
Sören TwarockMedical Faculty and University Hospital Düsseldorf, Institute of Translational Pharmacology Heinrich Heine University Düsseldorf Duesseldorf Germany.
Stefanie GeyhDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Kathrin NachtkampDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Patrick TressinDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Annika KasprzakDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.ORCID https://orcid.org/0000-0001-7642-6751
Felix MatkeyDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Titus WatrinDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Malika El YaoutiDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Ulrich GermingDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Sascha DietrichDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.
Guido KobbeDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf Duesseldorf Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a key treatment for hematologic malignancies, but donor selection impacts outcomes. Results: In a cohort of 152 patients undergoing allo-SCT from 2012 to 2023, haploidentical donors with post-transplant cyclophosphamide (PTCy) showed superior survival compared to 9/10 mismatched unrelated donors (MMUD). Cox regression analysis revealed that patients not in complete remission (CR) before transplantation particularly benefited from haplo donors, while those with 9/10 MMUD and lacking CR had worse outcomes. Conclusion: These results highlight the importance of donor selection, suggesting that haplo donors with PTCy may be preferable for patients not in CR, necessitating alternative approaches for others. Clinical trial registration: The authors have confirmed clinical trial registration is not needed for this submission.

Indexed as

BMTcellular therapieshematological malignanciestransplant

Identifiers

PMID40041662
PMCPMC11876775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.