Evidence map›Paper›PMID 40041570›Full record

ArticleBioMed research international2025

Expression of UCOE and HSP27 Molecular Elements to Improve the Stable Protein Production on HEK293 Cells.

Concepción Sosa-García, Uriel Abdallah Sánchez-Pacheco, Carlos Alberto Tavira-Montalvan, Angélica Meneses-Acosta

Abstract read
In one paragraph

Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Concepción Sosa-GarcíaLaboratory of Pharmaceutical Biotechnology, Faculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0009-0001-8126-4918
Uriel Abdallah Sánchez-PachecoLaboratory of Pharmaceutical Biotechnology, Faculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0009-0006-1448-6234
Carlos Alberto Tavira-MontalvanLaboratory of Pharmaceutical Biotechnology, Faculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0000-0002-0927-437X
Angélica Meneses-AcostaLaboratory of Pharmaceutical Biotechnology, Faculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0000-0003-2677-4939

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant proteins represent one of the greatest achievements of modern pharmaceutical biotechnology, as they are increasingly used across nearly all branches of medicine to treat a wide range of conditions. In response to this demand, various cell engineering approaches have been developed to improve their expression. Some of these approaches involve the use of genetic elements that prevent the silencing of the gene of interest, as well as the generation of resistant cell lines to inhibit or avoid programmed cell death (PCD). This research focuses on analyzing the effects of overexpression of UCOE elements and the HSP27 protein, both individually and together, on the production of human rIFN

Indexed as

HSP27 Heat-Shock ProteinsRecombinant ProteinsCell EngineeringHeat-Shock ProteinsHEK293 CellsHumansMolecular ChaperonesHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSPB1 protein, humanMolecular ChaperonesRecombinant ProteinsapoptosisautophagyHEK293HSP27IFNγprogrammed cell deathUCOE

Identifiers

PMID40041570
PMCPMC11879590

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.