Evidence map›Paper›PMID 40041543›Full record

ArticleNorth American Spine Society journal2025

Undetected low bone mineral density in patients undergoing lumbar fusion surgery-prevalence and risk factors.

Paul C Köhli, Jan Hambrecht, Jiaqi Zhu, Erika Chiapparelli, Lukas Schönnagel, Ali E Guven, Roland Duculan, Ellen Otto, Arne Kienzle, Gisberto Evangelisti and 8 more

Abstract read
In one paragraph

Article in North American Spine Society journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Paul C KöhliDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Jan HambrechtDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Jiaqi ZhuBiostatistics Core, Hospital for Special Surgery, New York, NY, United States.
Erika ChiapparelliDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Lukas SchönnagelDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Ali E GuvenDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Roland DuculanHospital for Special Surgery, Weill Cornell Medical College, New York, NY.
Ellen OttoCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.
Arne KienzleCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.
Gisberto EvangelistiDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Jennifer ShueDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Koki TsuchiyaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Marco D BurkhardDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Carol A MancusoHospital for Special Surgery, Weill Cornell Medical College, New York, NY.
Andrew A SamaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Federico P GirardiDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Frank P CammisaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.
Alexander P HughesDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sufficient bone quality is a prerequisite for low complication rates and satisfactory outcomes in lumbar fusion surgery (LFS). Low bone mineral density (BMD), including osteoporosis and osteopenia, is linked to adverse postoperative outcomes. Despite reports of a high prevalence of undiagnosed osteoporosis, it is uncertain which risk factors should guide preoperative BMD screening in LFS. Methods: This secondary cross-sectional analysis of a prospective institutional database at an academic spine center included adult patients undergoing LFS for degenerative conditions between 2014 and 2023. Opportunistic quantitative CT (qCT) at the L1/2 level was performed before surgery, and demographic and medical history data were extracted. Descriptive and comparative statistics, univariable and multivariable logistic regression were performed to determine risk factors for present and undiagnosed osteoporosis. Results: Of the 675 patients screened, 578 (54% female) were included after excluding those with preoperative lumbar CT scans not suitable for qCT. The median age was 65 years (IQR 58-72), and the median BMI of 28.9 kg/m Conclusions: This study found a high prevalence of abnormal BMD in LFS patients, with a significant proportion of undiagnosed osteoporosis. While osteoporosis was more common in females, male patients with osteoporosis were more frequently undiagnosed. Spine surgeons must remain vigilant about metabolic bone disease in LFS patients to ensure preoperative optimization and prevent complications.

Indexed as

Bone mineral densityLumbar fusion surgeryOsteopeniaOsteoporosisqCTSpinal fusion surgeryUndetectedUndiagnosed

Identifiers

PMID40041543
PMCPMC11876750

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.