ArticleAfrican journal of thoracic and critical care medicine2024
Safety and yield of sputum induction for diagnosis of pulmonary tuberculosis in children in a tertiary hospital in Ghana.
Article in African journal of thoracic and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A critical perspective on paediatric pulmonary tuberculosis and diagnostic advancements.African journal of thoracic and critical care medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Induced sputum (IS) is a sampling technique for obtaining lower airway samples for microbial investigations, including GeneXpert and culture for microbiological confirmation of Objectives: To investigate the safety and yield of IS in children admitted to a tertiary hospital in Ghana with presumed pulmonary tuberculosis (PTB). Methods: A prospective cross-sectional study was carried out in children aged 3 months - 14 years at Komfo Anokye Teaching Hospital in Kumasi, Ghana, over the 6-month period January - June 2022. All children with breathing difficulty and other signs of respiratory distress were given respiratory support, and IS samples were obtained when respiratory distress had resolved. One or two IS samples were collected from each child within 48 hours of admission by a trained nurse after at least 4 hours of fasting. Children were monitored during and for 30 minutes after the procedure, with recording of respiratory rate, oxygen saturation, temperature and pulse rate. They were also monitored for any adverse events such as vomiting, wheezing and nosebleeds. Results: A total of 144 children were sampled, with approximately two-thirds sampled a second time. Nearly half of the participants were aged <2 years (49.3%; n=71/144), and the median (interquartile range (IQR)) age was 2.5 (0.9 - 6.8) years. Ninety-eight children (68.1%) tested positive for PTB by Xpert Ultra, with 19/98 (19.4%) being rifampicin resistant; 47/102 (46.1%) were positive by Ziehl-Neelsen staining, and 57/102 (55.9%) were positive by Auramine O staining. Three children (2.1%) had an episode of epistaxis following the procedure. No other adverse events were observed. Measurements before and 30 minutes to 1 hour after the procedure (median (IQR)) were similar: temperature 36.5°C (36.5 - 37.5°C) v. 36.5°C (36.2 - 37.1°C), oxygen saturation 98% (92 - 99%) v. 98% (93 - 99%), pulse rate 120 (106 - 139) v. 125 (112 - 142) bpm, and respiratory rate 38 (30 - 48) v. 33 (30 - 45) cycles per minute. Conclusion: We found sputum induction to be a safe and well-tolerated procedure in the paediatric population, with minimal clinical risk and a high microbiological yield for PTB. Study synopsis:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.