Evidence map›Paper›PMID 40041395›Full record

ArticleBrain & spine2025

Spinal metastases at the thoracolumbar junction - Influencing factors for surgical decision-making according to a multicentric registry.

Vanessa Hubertus, Arthur Wagner, Arian Karbe, Leon-Gordian Leonhardt, Beate Kunze, Susanne Borchert, Fatma Kilinc, Michelle Mariño, Nitzan Nissimov, Charlotte Buhre and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain & spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Vanessa HubertusDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Arthur WagnerDepartment of Neurosurgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Arian KarbeDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Leon-Gordian LeonhardtDivision of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Beate KunzeSpine Surgery, Orthopedic Hospital Markgröningen gGmbH, Markgröningen, Germany.
Susanne BorchertSpine Surgery, Orthopedic Hospital Markgröningen gGmbH, Markgröningen, Germany.
Fatma KilincDepartment of Neurosurgery, University Hospital Frankfurt / Main, Frankfurt, Germany.
Michelle MariñoDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Nitzan NissimovDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Charlotte BuhreDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Marcus CzabankaDepartment of Neurosurgery, University Hospital Frankfurt / Main, Frankfurt, Germany.
Marc DreimannSpine Surgery, Orthopedic Hospital Markgröningen gGmbH, Markgröningen, Germany.
Sven O EickerDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lennart ViezensDivision of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hanno S MeyerDepartment of Neurosurgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Peter VajkoczyDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Bernhard MeyerDepartment of Neurosurgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Julia S OnkenDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Spinal metastases at the thoracolumbar junction (TLJ) pose a significant risk for spinal instability and necessitate special considerations regarding surgical management. Longer patient survival due to improved oncologic therapies may justify extensive instrumented surgery. Research question: The aim of this study was to analyze the standard of care in a large multicentric cohort of patients with TLJ metastases regarding surgical decision-making, management, and associated morbidity. Material and methods: Patients with surgically treated spinal metastases at the TLJ between 2010 and 2022 were enrolled at five academic tertiary spine centers. Epidemiological, surgical, clinical, and outcome data was assessed retrospectively. Surgical management was sorted according to three groups: decompression ( Results: The inclusion criteria was met by 396 patients, of which 59 (15%) were treated with decompression ( Discussion and conclusion: In this large multicentric patient cohort with TLJ metastases, the majority of patients (85%) were treated with instrumented spine surgery. The main factor for patient selection towards instrumented surgery was a higher SINS score. Long instrumentations for multisegmental disease at the TLJ were identified with higher risk for hardware-failure during follow-up. In those patients, frequent follow-up imaging is warranted. As postoperative survival is drastically reduced by the occurrence of postoperative complications, it is imperative to carefully select the individually appropriate extent of surgery in order to avoid postoperative complications.

Indexed as

Spinal metastasisSpinal oncologySpine instrumentationsurgical indicationThoracolumbar junction

Identifiers

PMID40041395
PMCPMC11876765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.