Observational studyFrontiers in endocrinology2025
Effect of sex, pubertal stage, body mass index, oral contraceptive use, and C-reactive protein on vitamin D binding protein reference values.
Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02550236 (Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases
Who cites it
1 citing paper in PubMed.
- Establishment of Serum 25-Hydroxyvitamin D Reference Range for Healthy Adult Men Not Using Vitamin D Supplements in Alqurayyat, Saudi Arabia.International journal of general medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Vitamin D binding protein (DBP) regulates the transport and availability of vitamin D. We aimed to establish age- and sex-specific reference ranges for serum concentrations of DBP in healthy infants, children, and adolescents. In addition, we investigated DBP's associations with age, sex, puberty, body mass index (BMI), and oral contraceptive use. Design and methods: 2,503 serum samples from children and adolescents aged 3 months to 17 years from the LIFE Child cohort were analyzed to study DBP levels in this population (49.3% female subjects, 50.7% male subjects). Age- and sex-dependent reference percentiles were established using generalized additive models. We used linear mixed effects models to assess DBP's associations with age, sex, pubertal status, the BMI standard deviation score (SDS), and oral contraceptives. To investigate associations between DBP and vitamin D metabolites, we applied univariate regression analysis. We used hierarchical regression models and linear mixed effects models to assess DBP's associations with bone parameters, hormones, and inflammatory markers. Results: Mean DBP values differed between males (347 mg/l) and females (366 mg/l) (p < 0.001). Age had no significant association with DBP levels. In both males and females, DBP levels remained relatively stable from infancy through late adolescence. Children and adolescents with obesity had lower mean DBP levels compared with normal-weight subjects (ß = -14.28, p < 0.001). The BMI-SDS was inversely associated with DBP levels in males (ß = -5.7, p < 0.001). Female subjects using oral contraceptives had higher levels of DBP (ß = 141.38, p < 0.001). DBP was positively associated with the vitamin D metabolites: 25(OH)D Conclusion: We established age- and sex-specific reference ranges for the serum concentration of DBP. We suggest that BMI, pubertal stages, oral contraceptive use, and inflammation markers need to be considered when interpreting DBP as a stabilizer and regulator of vitamin D metabolism and vitamin D status in children and adolescents. Clinical trial registration: ClinicalTrial.gov, identifier NCT02550236.
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