ArticleFrontiers in endocrinology2025
Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study.International journal of genomics · 2026Article
- Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt-FoxO signaling.Frontiers in immunology · 2026Article
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14 authors.
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Abstract
Background: Osteoporosis and obesity are both major global public health problems. Observational studies have found that osteoporosis might be related to obesity. Mendelian randomization (MR) analysis could overcome the limitations of observational studies in assessing causal relationships. Objective: This study aims to evaluate the causal potential relationship between obesity-related indicators and osteoporosis by using a two-sample MR analysis and to identify potential mediators. Method: A total of 53 obesity-related indicators, 3,282 plasma protein lists, and 452 blood metabolite lists were downloaded from the public data set as instrumental variables, and the osteoporosis GWAS data of the MRC IEU Open GWAS database was used as the outcome indicators. Using two-sample univariate MR, multivariate MR, and intermediate MR, the causal relationship and mediating factors between obesity-related indicators and osteoporosis were identified. Results: The IVW model results show that 31 obesity-related indicators may have a significant causal relationship with osteoporosis ( Conclusion: Obesity may confer a protective effect against osteoporosis, potentially mediated by EHMT2 in plasma proteins and alanine in blood metabolites. Further empirical research is required to fully elucidate the mechanisms behind the influence of obesity on osteoporosis. Interventions on obesity-related factors to reduce the risk of osteoporosis while controlling other adverse effects associated with obesity may require further research.
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