Evidence map›Paper›PMID 40041240›Full record

ArticleTherapeutic advances in gastroenterology2025

Reducing diagnostic delays of extraintestinal manifestations in inflammatory bowel disease: a comparative study of a multidisciplinary outpatient clinic versus conventional referral specialists.

Olga Maria Nardone, Giulio Calabrese, Alessia La Mantia, Guido Daniele Villani, Matteo Megna, Sara Cacciapuoti, Francesca Foglia, Rosario Peluso, Ermelinda D'Alessandro, Mario Ferrante and 4 more

Abstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Models of outpatient care delivery in inflammatory bowel disease: a scoping review.Journal of the Canadian Association of Gastroenterology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Olga Maria NardoneGastroenterology Unit, Department of Public Health, University of Naples Federico II, via S. Pansini 5, Naples 80131, Italy.ORCID https://orcid.org/0000-0002-9554-4785
Giulio CalabreseGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Alessia La MantiaGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0009-0006-0017-2576
Guido Daniele VillaniGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Matteo MegnaSection of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Sara CacciapuotiSection of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Francesca FogliaRheumatology Unit, Department of Clinical Medicine and Surgery, School of Medicine, University Federico II of Naples, Naples, Italy.
Rosario PelusoRheumatology Unit, Department of Clinical Medicine and Surgery, School of Medicine, University Federico II of Naples, Naples, Italy.
Ermelinda D'AlessandroGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Mario FerranteGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Anna TestaGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Alessia Dalila GuarinoGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Antonio RispoGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Fabiana CastiglioneGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity in diagnostic criteria and the lack of a standardised definition and validated diagnostic pathways. Delays in recognising and treating EIMs can lead to significant disease progression. Therefore, early detection and treatment are crucial. Objectives: We aimed to assess the effectiveness of a dedicated immune-mediated inflammatory diseases (IMIDs) clinic in reducing EIM diagnostic delays and improving patients' outcomes. Design: A single-centre observational study was conducted, including IBD patients presenting with EIMs red flags. Methods: We compared the EIMs diagnostic delay between patients who attended a multidisciplinary IMID outpatient clinic (IMID-G) and those who attended individual referral specialists representing the standard outpatient clinic group (SOC-G). We further evaluated the impact of diagnostic timing on 18-month clinical outcomes, including therapeutic changes, steroid and immunosuppressant use and biological therapy switch/swap. Results: We enrolled 238 IBD patients, 127 in the IMID-G and 111 in the SOC-G. The average time to EIM diagnosis was 2.48 ± 1.8 and 5.36 ± 2.3 months for the IMID and SOC-Gs (Δ = 2.88 months, Conclusion: Attending a dedicated IMID clinic can enhance the diagnostic process for EIMs in IBD patients, thereby reducing diagnostic delays and allowing early interventions to avoid disease progression.

Indexed as

diagnostic delayextraintestinal manifestationsinflammatory bowel diseasemultidisciplinary team

Identifiers

PMID40041240
PMCPMC11877470

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.