ArticleVeterinary medicine international2025
A-Kinase Anchor Protein 4 (proAKAP4): Protein Molecule-Based Fertility Marker of Indonesian Dairy Bull and Its Correlation With Frozen-Thawed Sperm Quality.
Article in Veterinary medicine international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Exploration of Novel Markers in Tan Sheep Spermatogenesis.Animals : an open access journal from MDPI · 2026Article
- Sperm capacitation in bulls, rams, bucks, and boars: molecular mechanisms and species-specific differences.Frontiers in veterinary science · 2026Review
- Unveiling novel insights into the role and characteristics of sperm heat shock protein 70 in indigenous Donggala bulls: implications for molecular-based motility markers.Archives animal breeding · 2026Article
- Molecular weight-based profiling of sperm proteins and their association with semen quality in Kokok Balenggek roosters.Journal of advanced veterinary and animal research · 2025Article
- Precursor A-Kinase Anchor Protein 4 as a Predictive Biomarker of Post-Thaw Semen Quality in Goats.Veterinary sciences · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
The precursor protein of A-kinase anchor protein 4 (proAKAP4), which is abundant in the fibrous sheath of sperm, plays an essential role in sperm motility and has been developed into one of the candidate molecular-based fertility markers. This study aimed to identify proAKAP4 in the sperm of Indonesian dairy bulls and to investigate its correlation with various sperm quality characteristics. The findings are expected to be applied and developed to optimize the use of superior dairy bulls. Frozen semen from 20 Indonesian dairy bulls were used, which had previously been classified based on their fertility levels into two groups: high fertility (HF) and low fertility (LF). Analysis of frozen-thawed sperm quality, such as progressive and total motility, sperm kinematics, membrane integrity, mitochondrial membrane potential, acrosome integrity, and capacitation status, was carried out in both groups. ProAKAP4 protein in frozen-thawed sperm was analyzed using the Bull 4MID Kit with the ELISA technique. Each dairy bull showed varying proAKAP4 abundance (
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