ArticleSurgical neurology international2025
Aquaporin-9 as a biomarker for hydrocephalus: Insights from experimental rat models.
Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Hydrocephalus: Molecular and Neuroimaging Biomarkers in Diagnosis and Management.Biomedicines · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hydrocephalus, characterized by ventricular enlargement often associated with elevated intracranial pressure, necessitates reliable biomarkers for accurate diagnosis. Aquaporin-9 (AQP-9), localized at the interface of cerebrospinal fluid (CSF) spaces and blood vessels, plays a critical role in brain water homeostasis but remains underexplored in the context of hydrocephalus. Further investigation into AQP-9 expression in CSF is essential to elucidate its potential as a diagnostic biomarker and its role in hydrocephalus pathophysiology. Methods: This experimental study utilized 10-12-week-old Sprague-Dawley rats ( Results: AQP-9 levels were significantly elevated in hydrocephalic mice compared to controls, with the highest levels on day 21 (887.62 ± 88.72). CSF drainage resulted in a notable reduction in AQP-9 levels at all time points. Statistical analysis confirmed significant differences across groups ( Conclusion: AQP-9 shows promise as a biomarker for hydrocephalus, with levels reflecting disease progression and decreasing after CSF drainage. This highlights its potential for diagnosis and therapeutic monitoring, warranting further validation.
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