ReviewChem & bio engineering2025
Nucleic Acid Framework-Enabled Spatial Organization for Biological Applications.
Review in Chem & bio engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Nucleic acid frameworks (NAFs) are artificially prepared from natural nucleic acids with a precise size and structure. DNA origami exhibits controllable 2D lamellar structure and thus is easily used to construct 3D structures with different morphologies. Tetrahedral DNA nanostructures (TDNs) are prepared with four DNA strands that hybridize to each other with a tetrahedral structure. Here we summarize molecular spatial organization with DNA origami and TDNs as models for 2D- and 3D-recombinations, discuss NAF-based biomimicking of proteins and biomembranes, and introduce the identification probes, functional groups, and intercalators for biosensing, bioimaging, and nanomedicine therapy. NAFs are also extended to applications to guide the formation of inorganic nanoparticles with precise size and structure. Thus, the NAFs exhibit special organization, are easy to functionalize, and are becoming an important platform for interdisciplinary study and applications, such as nanotechnology, biochemistry, synthetic biology, and nanomedicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.