ArticleERJ open research2025
Optimal spirometry thresholds for the prediction of chronic airflow obstruction: a multinational longitudinal study.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Expiratory time constant patterns reveal obstructive lung mechanics in non-obstructive spirometry.PLOS digital health · 2026Article
- Derivation and validation of a pre-bronchodilator FEV1/FVC threshold for point-of-care diagnosis triage of COPD in primary care: a multi-cohort population-based study.The Lancet regional health. Western Pacific · 2026Article
- Small Airway Disease in Pre-COPD and Early COPD: Insights Into the Pulmonary "Silent Zone".International journal of chronic obstructive pulmonary disease · 2026Review
- Contemporary Concise Review 2024: Chronic Obstructive Pulmonary Disease.Respirology (Carlton, Vic.) · 2025Review
- Bronchodilator responsiveness and future chronic airflow obstruction: a multinational longitudinal study.EClinicalMedicine · 2025Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
Introduction: Chronic airflow obstruction is key for COPD diagnosis, but strategies for its early detection are limited. We aimed to define the optimal z-score thresholds for spirometry parameters to discriminate chronic airflow obstruction incidence. Methods: The Burden of Obstructive Lung Disease study is a multinational cohort study. Information on respiratory symptoms was collected and pre- and post-bronchodilator spirometry was performed at baseline. 18 study sites were followed-up with repeat measurements after a median of 8.4 years. We converted lung function measurements into z-scores using the Third National Health and Nutrition Survey reference equations. We used the Youden index to calculate the optimal z-score thresholds for discriminating chronic airflow obstruction incidence. We further examined differences by smoking status. Results: We analysed data from 3057 adults (57% female, mean age: 51 years at baseline). Spirometry parameters were good at discriminating chronic airflow obstruction incidence (area under the curve 0.80-0.84), while respiratory symptoms performed poorly. The optimal z-score threshold was identified for pre-bronchodilator forced expiratory volume in 1 s to forced vital capacity ratio (FEV Conclusions: Spirometry is better than respiratory symptoms at predicting chronic airflow obstruction incidence. A pre-bronchodilator FEV
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.