Evidence map›Paper›PMID 40040889›Full record

ArticleERJ open research2025

The lung proteome in HIV-associated obstructive lung disease.

Sarah Samorodnitsky, Danielle Weise, Eric F Lock, Ken M Kunisaki, Alison Morris, Janice M Leung, Monica Kruk, Laurie Parker, Pratik Jagtap, Timothy J Griffin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah SamorodnitskyBiostatistics Division, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Danielle WeiseDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Eric F LockBiostatistics Division, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Ken M KunisakiDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Alison MorrisDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Janice M LeungDepartment of Medicine, University of British Columbia, Vancouver, Canada.
Monica KrukDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Laurie ParkerDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Pratik JagtapDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Timothy J GriffinDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0001-6801-2559
Chris H WendtDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.

Funding

Spingolipids in HIV-associated Chronic Obstructive Pulmonary DiseaseR01HL140971 · NHLBI · UNIVERSITY OF MINNESOTA · PI GRIFFIN, TIMOTHY J., KUNISAKI, KEN M. · 2018 to 2021
$2.7M
A transformative next-generation Orbitrap Tribrid system for the UMN and Upper MidwestS10OD028717 · OD · UNIVERSITY OF MINNESOTA · PI GRIFFIN, TIMOTHY J. · 2020 to 2020
$1.2M
NHLBI NIH HHS R01 HL140971NIH HHS S10 OD028717
6 · The paper itself

Abstract

Rationale: Obstructive lung disease is increasingly common among persons living with HIV (PLWH). There are currently no validated biomarkers that identify individuals at risk of developing obstructive lung disease (OLD), and specific mechanisms contributing to HIV-associated OLD remain elusive, independent of smoking. We sought to identify biomarkers and biological pathways associated with OLD using a broad proteomic approach. Methods: We performed tandem mass tagging and mass spectrometry (MS) analysis on bronchoalveolar lavage fluid samples from persons living with HIV with OLD (n=26) and without OLD (n=26). We combined untargeted MS with a targeted SomaScan aptamer-based approach. We used Pearson correlation tests to identify associations between each protein and lung function (forced expiratory volume in 1 s (FEV Measurements and main results: We identified over 3800 proteins by MS and identified 254 proteins that correlated with FEV Conclusions: Protein expression differs in the lung of PLWH and decreased lung function (FEV

Identifiers

PMID40040889
PMCPMC11874292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.