Evidence map›Paper›PMID 40040852›Full record

ArticleJournal of clinical and experimental hepatology

Stanozolol-induced Liver Injury: A Distinctive Cholestatic Clinical and Biochemical Phenotype at Presentation.

Vinícius Nunes, Maria I Schinoni, Fernando Bessone, Maria I Lucena, Inmaculada Medina-Cáliz, Nelia Hernandez, Maria C Moura Costa, Isadora Lins, Ana J Cardoso, Barbara Freire and 4 more

Abstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vinícius NunesFederal University of Bahia, Brazil.
Maria I SchinoniFederal University of Bahia, Brazil.
Fernando BessoneHospital Provincial del Centenario, University of Rosario School of Medicine, Rosario, Argentina.
Maria I LucenaServicios de Aparato Digestivo and Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Universidad de Málaga, Málaga, Spain.
Inmaculada Medina-CálizServicios de Aparato Digestivo and Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Universidad de Málaga, Málaga, Spain.
Nelia HernandezHospital de Clínicas, Universidad de la República, Montevideo, Uruguay.
Maria C Moura CostaFederal University of Bahia, Brazil.
Isadora LinsFederal University of Bahia, Brazil.
Ana J CardosoUniversity of São Paulo, Brazil.
Barbara FreireBahiana School of Medicine and Public Health, Bahia, Brazil.
Leonardo SchiavonFederal University of Santa Catarina, Brazil.
Marcelo SilvaFederal University of Bahia, Brazil.
Eduardo R CançadoHospital Provincial del Centenario, University of Rosario School of Medicine, Rosario, Argentina.
Raymundo ParanáFederal University of Bahia, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & aims: The misuse of Anabolic Androgenic Steroids (AAS), including Stanozolol, for performance enhancement has emerged as a significant cause of liver damage. This study aims to elucidate the distinctive hepatotoxicity profiles induced by Stanozolol. Methods: Eighteen individuals were prospectively evaluated by the Latin American DILI Registry from 2013 to 2023. Data regarding Stanozolol administration, symptoms onset, and clinical manifestations were collected. Comprehensive assessments including serologies, abdominal imaging, and in some cases, liver biopsies were performed to identify Stanozolol-induced liver injury and exclude other etiologies. Results: All patients were young males aged between 19 and 48, utilizing Stanozolol for aesthetic purposes. The mean latency to symptom onset was 55 days. Predominant symptoms included jaundice and pruritus. Elevated total bilirubin levels were observed in all cases, while gamma-glutamyl transferase levels remained within or slightly above normal ranges. Concurrent use of other substances was reported in ten cases, showcasing a trend of poly-substance abuse. Conclusions: The study identified a specific biochemical profile of Stanozolol-induced liver injury in young men using it for aesthetic purposes. The characteristic liver injury profile has marked elevation of bilirubin, mild rise in transaminases, and near-normal GGT.

Indexed as

anabolic androgenic steroidsbland cholestasischolestasisdrug induced liver injury

Identifiers

PMID40040852
PMCPMC11872475

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.