Evidence map›Paper›PMID 40040822›Full record

ReviewExploration (Beijing, China)2025

Harnessing stimuli-responsive biomaterials for advanced biomedical applications.

Ziming Liao, Tingting Liu, Zhimin Yao, Tian Hu, Xiaoyuan Ji, Bin Yao

Abstract readReview
In one paragraph

Review in Exploration (Beijing, China), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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  11. Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.Journal of biomedical materials research. Part B, Applied biomaterials · 2026
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  12. Article
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  18. Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ziming LiaoAcademy of Medical Engineering and Translational Medicine Tianjin University Tianjin P. R. China.
Tingting LiuDivision of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts USA.
Zhimin YaoSichuan Preschool Educators' College Mianyang P. R. China.
Tian HuMRC Human Immunology Unit MRC Weatherall Institute of Molecular Medicine, University of Oxford John Radcliffe Hospital Oxford UK.
Xiaoyuan JiAcademy of Medical Engineering and Translational Medicine Tianjin University Tianjin P. R. China.ORCID https://orcid.org/0000-0002-6768-2304
Bin YaoAcademy of Medical Engineering and Translational Medicine Tianjin University Tianjin P. R. China.ORCID https://orcid.org/0000-0002-0709-8683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular behavior toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, and magnetism, simultaneously harnessed through biomaterial-mediated responses. These external triggers become focal points within the body due to interactions with biomaterials, facilitating a range of cellular pathways: electrical signal transmission, biochemical cues, drug release, cell loading, and modulation of mechanical stress. Stimulus-responsive biomaterials hold immense potential in biomedical research, establishing themselves as a pivotal focal point in interdisciplinary pursuits. This comprehensive review systematically elucidates prevalent physical stimuli and their corresponding biomaterial response mechanisms. Moreover, it delves deeply into the application of biomaterials within the domain of biomedicine. A balanced assessment of distinct physical stimulation techniques is provided, along with a discussion of their merits and limitations. The review aims to shed light on the future trajectory of physical stimulus-responsive biomaterials in disease treatment and outline their application prospects and potential for future development. This review is poised to spark novel concepts for advancing intelligent, stimulus-responsive biomaterials.

Indexed as

biomaterialsbiomedicalphysical stimulationstimulus‐responsive

Identifiers

PMID40040822
PMCPMC11875454

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.