Evidence map›Paper›PMID 40040788›Full record

ReviewFrontiers in cell and developmental biology2025

Neuron-to-glia and glia-to-glia signaling directs critical period experience-dependent synapse pruning.

Nichalas Nelson, Vanessa Miller, Kendal Broadie

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. The Repair Manual of a Fruit Fly Brain.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nichalas NelsonDepartment of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN, United States.
Vanessa MillerDepartment of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN, United States.
Kendal BroadieDepartment of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN, United States.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Glial roles in experience-dependent critical period remodelingR01NS132867 · NINDS · VANDERBILT UNIVERSITY · PI Kendal Broadie · 2024 to 2026
$1.2M
NICHD NIH HHS P50 HD103537NINDS NIH HHS R01 NS132867
6 · The paper itself

Abstract

Experience-dependent glial synapse pruning plays a pivotal role in sculpting brain circuit connectivity during early-life critical periods of development. Recent advances suggest a layered cascade of intercellular communication between neurons and glial phagocytes orchestrates this precise, targeted synapse elimination. We focus here on studies from the powerful

Indexed as

Draper/MEGF-10Drosophilainsulinphosphatidylserineserotonin

Identifiers

PMID40040788
PMCPMC11876149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.